Clinical Pediatrics: Open Access

Clinical Pediatrics: Open Access

Basic info

  • Publisher: LONGDOM PUBLISHING SL
  • Country of publisher: spain
  • Date added to EuroPub: 2019/Nov/23

Subject and more

  • LCC Subject Category: Pediatrics, Pediatrics
  • Publisher's keywords:
  • Language of fulltext: english

Publication charges

  • Article Processing Charges (APCs): No
  • Submission charges: No
  • Waiver policy for charges? No

Editorial information

Open access & licensing

  • Type of License:
  • License terms
  • Open Access Statement: No
  • Year open access content began: 2016
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier:
  • Content digitally archived in:
  • Deposit policy registered in:

This journal has '4' articles

Effect of Cannabis Legalization on US Autism Incidence and Medium Term Projections

Effect of Cannabis Legalization on US Autism Incidence and Medium Term Projections

Authors: Albert q Stuart Reece, Gary Kenneth Hulse
( 0 downloads)
Abstract

Objective: In that cannabis use has been linked with the development of autism spectrum disorder like conditions in gestationally exposed children, we set out to explore the extent to which rising cannabis use might contribute to the rising autism epidemic. Methods: Datasets from US Department of Education Individuals with Disabilities Act (IDEA), National Survey of Drug Use and Health, and CDC’s Autism and Developmental Disabilities Monitoring (ADDM) Network were investigated. Data on legal status was derived from SAMHSA. Results: IDEA had N=1,023 and ADDM N=87. Modelling of IDEA consistently showed that models quadratic-intime out-performed linear-only models (ANOVA p<2.0x10-16). In both datasets liberalization of cannabis legislation was associated with increased ASD (p<10-9 and p<0.05 respectively). Slopes of: ASD vs. time, Cannabis vs. time and ASD vs. cannabis curves were shown to be related on graphical analysis by geofacet plots and tanglegrams (entanglement=0.3326). CDC’s ADDM network quoted US autism incidence 168/10,000 in 2014. IDEA projections indicated rates 108.57, 131.67 and 166.49 in cannabis-illegal, -medical and -decriminalized states rising exponentially to 282.37, 396.91 and 455.54 by 2030. Conclusion: ASD is the commonest form of cannabis-associated clinical teratology. Using two independent datasets and two categorization methods we confirmed that medical, decriminalized and legal cannabis regimes are associated with higher rates of ASD than illegal ones. Findings are consistent with molecular, cellular and epigenetic mechanisms. Formerly quadratic regression curves become exponential when projected forwards to 2030; predict a lower quantum than the 2014 ADDM CDC figure; and indicate a 60% excess of cases in legal states by 2030.

Keywords: Cannabis. Cannabinoids. Cannabidiol. Cannabinol. Cannabichromene. Tetrahydrocannabinol
Epidemiological Associations of Various Substances and Multiple Cannabinoids with Autism in USA

Epidemiological Associations of Various Substances and Multiple Cannabinoids with Autism in USA

Authors: Albert Stuart Reece, Gary Kenneth Hulse
( 0 downloads)
Abstract

Introduction: Autistic Spectrum Disorder (ASD) is increasing in across USA. Paediatricians and physicians in both Colorado and Australia continue to see high caseloads however this prevalence uptick remains largely unexplained. Since drug use is an obvious potential source of developmental brain damage the present study was undertaken to study drug-ASD associations at state level.Methods: Existing datasets from the US Department of Education Individuals with Disabilities Act, the Substance Abuse and Mental Health Services Administration National Survey of Drug Use and Health, and the Drug Enforcement Agency cannabinoid concentration in seizures were re-analyzed.Results: ASD rates are high and rising fastest in Colorado, Maine, Massachusetts, Oregon, Rhode Island and New Jersey but falling in Oklahoma and Iowa. When the nine highest cannabis use states are grouped together ASD is rising significantly faster there than elsewhere (time:status interaction in quadratic mixed effects model p<0.0001). On univariate regression ASD rate was significantly positively associated with alcohol and cannabis exposure and with the cannabinoids Δ9-tetrahydrocannabinol, cannabinol, cannabichromene, cannabigerol and tetrahydrocannabivarin. These effects remained after multivariate adjustment for Δ9-tetrahydrocannabinol and cannabidiol (from p<0.0001). Cannabidiol correlated with ASD rate when a three year lag was introduced (R=0.7483, p=0.0032).Conclusion: These data show that increased cannabinoid exposure explains on bivariate and multivariate regression much of the recent rise in ASD across USA, and in the context of other reports, also at some local cluster levels. Together with numerous mechanistic reports these data argue for causality and indicate a large case-control study. ASD-like neurobehavioural toxicological syndromes likely represent the commonest form of cannabis-related teratology following peri-gestational exposure

Keywords: Cannabis. Opioids. Cannabidiol. Cannabinol. Tetrahydrocannabinol. Autism spectrum disorder
The Outbreak of Acinetobacter baumannii over a 19 month Period in a Teaching Hospital Neonatal Intensive Care Unit

The Outbreak of Acinetobacter baumannii over a 19 month Period in a Teaching Hospital Neonatal Intensive Care Unit

Authors: Hosein Dalili, Fatemeh Nayeri, Mamak Shariat, Nahid Farrokhzad, Leyla Sahebi
( 0 downloads)
Abstract

Objective: We investigated a long outbreak of a nosocomial infection of Acinetobacter baumannii (A. baumannii) in the Neonatal Intensive Care Unit (NICU) of Vali-Asr Teaching Hospital in Tehran, Iran. Methods: Within 19 months period, 25 neonates infected with A. baumannii were discovered. We divided the outbreak period into two groups according to the time they were infected. Group 1 was comprised of cases infected with A. baumannii from February to May 2016 (12 cases), and group 2 was neonates infected from November 2014 to January 2016 (13 cases). Identification of A. baumannii was executed by the phenotypic standards. Logistic regression analysis and Multiple Correspondence Analyses (MCA) were used for comparison of groups with various variables. Results: This outbreak had a common source with intermittent exposure, it ascended gradually and plateaued. Overall, 68.0% of the neonates had a birth weight of 2,499 g or less, and 84% were born preterm. Of the 25 infants, bloodstream involvement was present in 8 (66.7%) and 10 (76.9%) (p-value=0.450), and infection in trachea occurred in 7 (53.8%) and 3 (25.0%) (p-value=0.144) in group 1 and 2 respectively. In multiple logistic regression analysis, the number of prescribed antibiotics had a significant positive effect on increasing the slope in the epidemic curve (Group 1). The first and second dimensions presented in MCA were 54.25% and 20.45% respectively. Three categories concluded prescription of amphotericin, fluconazole, and being in group 1 was placed in very close coordination both in dimension 1 and 2.Conclusion: It seems that the antifungals and number of prescribed antibiotics played an important role in intensifying the outbreak of A. baumannii infection.

Keywords: Acinetobacter baumannii. Outbreak. Neonatal Intensive Care Units (NICU). Nosocomial Infection
Comparison of Homozygous for Delta F508 Mutation Nutritional Status, Lung Function Outcomes, Bacterial Growth, Antibiotic Treatments and Therapeutic Outcomes between the Amish and Non-Amish in a Single Pediatric Cystic Fibrosis Centre: A Retrospective Case-Controlled Study

Comparison of Homozygous for Delta F508 Mutation Nutritional Status, Lung Function Outcomes, Bacterial Growth, Antibiotic Treatments and Therapeutic Outcomes between the Amish and Non-Amish in a Single Pediatric Cystic Fibrosis Centre: A Retrospective Case-Controlled Study

Authors: Rajeswary Padman Padmalingam, Denise Gilham, Tina Laturner, Ron Jones, Gordon Bokhart, Alyaa Hussien, Chelsea Hamilton, Abeer Omar, Rachel McCafferty
( 0 downloads)
Abstract

There exists evident differences in the health and the care received of the Amish people in comparison to the general population. Amish patients were 100% homozygous for delta F508 mutation versus 12% in the non-Amish population (p=0.057). The Amish community was prescribed dietary supplements at a rate of 89% versus 50% for non-Amish (p=0.087). BMI>75th percentile was 51.25% in Amish patients and 61.25% in non-Amish patients (p=0.31). Mean FEV1 value was 83.6% versus 100% while mean FEF 25-75 value was 58% versus 86% for Amish and non Amish people respectively. There was substantial variance in the number of episodes of the same infection per patient between Amish and non-Amish population (1 IQR 0–1 versus 0 IQR 0–1; p=0.012). The rate of antibiotic prescribing per patient in the Amish group was 7.9 perceptions versus 2.2 prescriptions. The study aims to create the best possible treatment and the highest quality of life for patients with cystic fibrosis. Our manuscript creates a paradigm for future studies on the delta F508 mutation, nutrition supplements, Body Mass Index (BMI), Forced Expiratory Volume in 1 second (FEV1), Forced Expiratory Flow (FEF 25-75), airway microbial organisms and changes in antibiotic treatments in Amish compared to the non-Amish group, as well as developing a platform for an Amish community health program.

Keywords: Delta mutation outcomes. Nutritional status. Lung function. Antibiotic therapeutic. Amish. Non-Amish Pediatric. Cystic fibrosis

About Europub

EuroPub is a comprehensive, multipurpose database covering scholarly literature, with indexed records from active, authoritative journals, and indexes articles from journals all over the world. The result is an exhaustive database that assists research in every field. Easy access to a vast database at one place, reduces searching and data reviewing time considerably and helps authors in preparing new articles to a great extent. EuroPub aims at increasing the visibility of open access scholarly journals, thereby promoting their increased usage and impact.