TMR Integrative Medicine

TMR Integrative Medicine

Basic info

  • Publisher: TMR publishing group
  • Country of publisher: new zealand
  • Date added to EuroPub: 2020/Jan/14

Subject and more

  • LCC Subject Category: Medicine
  • Publisher's keywords: Medicine, Integrative Medicine, Therapy
  • Language of fulltext: english
  • Time from submission to publication: 7 weeks

Publication charges

  • Article Processing Charges (APCs): No
  • Submission charges: No
  • Waiver policy for charges? No

Open access & licensing

  • Type of License: CC BY
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2017
  • Does the author retain unrestricted copyright? True
  • Does the author retain publishing rights? True

Best practice polices

  • Permanent article identifier: DOI
  • Content digitally archived in: National Library of New Zealand
  • Deposit policy registered in: None

This journal has '11' articles

Application of external treatment of traditional Chinese medicine in the treatment of cancer-related fatigue

Application of external treatment of traditional Chinese medicine in the treatment of cancer-related fatigue

Authors: Ting Yu, Jin-Lin Wu, Jia Wang, Dong-Xin Tang
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Abstract

External treatment of traditional Chinese medicine (TCM), also known as external treatment of internal diseases, has many advantages, such as simple, easy to operate, cost-effective and so on. Therefore, external treatment of TCM is favored by the majority of medical workers. By consulting the domestic literature reports on the treatment of cancer-related fatigue (CRF), it is found that the external treatment of TCM has a significant effect on the intervention of CRF, and has a good effect on reducing fatigue, improving the quality of life and prolonging the survival time. The purpose of this paper is to summarize the application of several external treatments in this disease, and to provide a variety of references for clinical treatment of CRF.

Keywords: External treatment of traditional Chinese medicine, Cancer-related fatigue, Clinical application, Traditional Chinese medicine
Quantitative and qualitative comparison of neonatal screening plan for the identification of hypothyroid neonates between Nahavand and Kashmar cities in 2016–2017 (respectively in the west and east of Iran)

Quantitative and qualitative comparison of neonatal screening plan for the identification of hypothyroid neonates between Nahavand and Kashmar cities in 2016–2017 (respectively in the west and east of Iran)

Authors: Maryam Soori, Sedigheh Soleymani, Samira Tabaei, Manoochehr Solgi
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Abstract

Background: Congenital hypothyroidism is the result of a reduction in thyroid hormone production or a decrease in the activity of thyroid hormone receptors and is one of the most preventable causes of mental retardation, deafness, and heart problems in the world. This study aimed to compare the prevalence of congenital hypothyroidism between Nahavand in the west of Iran and Kashmar in the east of Iran during the years 2016–2017. Methods: This is a cross-sectional descriptive study on neonates born in April 2016 to March 2018 in two cities of Nahavand and Kashmar. A few drops of blood from a baby's heel in 3–5 birthdays on a special filter paper (S & S903) became blood samples from the pelvic floor were filtered and dried. The valuation of the samples was performed by the enzyme linked immunosorbent assay method by evaluating the thyroid stimulating hormone. Premature infants, underweight (less than 2,500 grams), a weight of over 4 kg, multiple births, or newborns requiring blood transfusions or any newborn needed to be retaken to the test after two weeks. Results: In the city of Nahavand, the incidence of neonatal hypothyroidism in the years 2016 and 2017 were 6.7 and 9.09 per 1,000 live births. And for the city of Kashmar, this number increased to 5.6 and 4.3 per 1,000 births in 2016 and 2017, respectively. The mean rate of participation in the screening program in the first 3–5 days of birth in Nahavand during two years was 2016 and 2017 to 78.7% and in Kashmar about 94%, which indicates the higher participation of Kashmar. In the city of Nahavand, 64.6% of cases of hypothyroidism reported in boys' neonates and 51.5% of male children in the Kashmar city. Conclusion: The results of our survey indicates that the prevalence of hypothyroidism is high in both Kashmar in eastern Iran and Nahavand in western Iran. Especially in Nahavand city of western Iran, where the prevalence of hypothyroidism is higher than global and internal statistics. Further surveys are required to elucidate the role of iodine deficiency and family marriage in the hereafter.

Keywords: Neonatal hypothyroidism, Screening, Special filter paper, Mental retardation, Prevalence, Iran
The use of traditional Chinese medicine internally and externally combined with auricular acupuncture point bloodletting in the treatment of vulvar leukoplakia

The use of traditional Chinese medicine internally and externally combined with auricular acupuncture point bloodletting in the treatment of vulvar leukoplakia

Authors: Yan-Yin Ji, Shu-Ning Liu, Xin Ping, Shao-Kun Qin
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Abstract

Vulvar leukoplakia refers to the chronic disease of degeneration and hypopigmentation of the skin and mucous membrane of the vulva with unbearable itching in women, seriously affecting the quality of life. The main treatment of western medicine for vulvar leukoplakia is the external use of glucocorticoids or estrogen, resulting to the high recurrence rate and side effects. Traditional Chinese medicine (TCM) has the characteristics of the overall concept and dialectical treatment with a variety of ways. Literature review in recent years found that the treatment of TCM decoction combined with external therapies, such as external fumigation, acupuncture and other treatments, or the combination of TCM decoction and external western medicine hormone ointment, can obtain good effects in vulvar leukoplakia. During the clinical practice, we found that the use of TCM internally and externally combined with auricular acupuncture point bloodletting was highly effective with unique advantages in the treatment of vulvar leukoplakia, providing the ideas guidance for clinicians.

Keywords: Vulvar leukoplakia, Traditional Chinese medicine (TCM), External therapy, Auricular acupuncture point bloodletting
Bioinformatic analysis reveals novel biomarkers and candidate drug compositions in prostate cancer

Bioinformatic analysis reveals novel biomarkers and candidate drug compositions in prostate cancer

Authors: Yi-Dan Sun, Ying Zhang, Shi-Qi Ren, Zi-Heng Wang, Pei-Ying Yang, Ying-Jie Jia
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Abstract

As prostate cancer (PC) patients do more and more genome sequencing, we can predict prognosis through individual oncogenic mutations. Although great success have been made to clarify the incidence of PC, the mechanisms was not completely understood. Recurrence and metastasis of PC remains to be resolved, and novel therapeutic targets need to be found urgently. Microarray datasets GSE6919, GSE55945 and GSE46602 about the PC tissues vs. normal organizations, were obtained from Gene Expression Omnibus. In this study, 86 differentially expressed genes were determined having more important clinical significance in the process of PC. 29 hub genes significantly enriched in biological processes were analyzed using Cytoscape. The function of these hub genes included the effect of cellular process, skeletal system development, cholesterol transport, regulation of protein oligomerization and cellular component biogenesis, enzyme inhibitor activity and so on. The three of these hub genes were picked out because of their relationships, which can be used as a potential target for the diagnosis and the direction of therapy. And drug predictions were designed for these candidate target molecules, providing direction for future treatment of PC.

Keywords: Prostate cancer, Bioinformatic analysis, Candidate target molecules, Differentially expressed genes (DEGs)
Research progress in traditional Chinese medicine treatment of contact dermatitis

Research progress in traditional Chinese medicine treatment of contact dermatitis

Authors: Jin-Yue Ting, Liu-Tian Yun
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Abstract

Contact dermatitis is one of the common diseases in dermatology in clinical practice. In recent years, the incidence of the disease has been increasing year by year. Clinically, antihistamines and hormones are often taken for symptomatic treatment. However, long-term repeated use will cause more serious symptoms, such as redness, swelling, and itching in the affected part of the patient. Traditional Chinese medicine (TCM) treats this disease with Chinese medicine decoction, Chinese patent medicine, hydropathic compress, acupuncture, etc., which have significant curative effect, and not only can relieve the patient's symptoms, but also not easy to relapse. Now, the progress of TCM treatment of this disease is reviewed in detail from two aspects: the internal treatment of TCM and the external treatment of TCM.

Keywords: Contact dermatitis, Traditional Chinese medicine, Treatment, Research progress
Research progress on self-efficacy in patients with total hip replacement

Research progress on self-efficacy in patients with total hip replacement

Authors: Xiao-Xiao Yang, Yuan-Yuan Chen, Fan-Jie Meng
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Abstract

Total hip replacement (THR) is an artificial hip joint prosthesis that replaces the damaged femoral head. For the good therapeutic effects, it has been widely used, while also brings a great negative problems at same time, especially the psychological problems. After THR, the patient has obvious motility symptoms of fear of movement, and shows a series of manifestations such as fear of activity and fall. However, for people with high self-efficacy, the degree of activity and fear is lower, with a good mental state. The effects of self-efficacy on rehabilitation behavior and prognosis of patients with THR were discussed from the aspects of activity ability, psychological state and quality of life. This paper sorts out the current situation of intervention research on self-efficacy of THR patients, and provides theoretical basis for further improving the self-efficacy of THR patients. Through these studies to understand how to improve patients' self-efficacy and reduce the fear of activity, obtain postoperative activity related knowledge, finally promote the limb functional recovery.

Keywords: Total hip replacement, Psychological problems, Self-efficacy, Review
Treating epilepsy based on phlegm-turbidity syndrome

Treating epilepsy based on phlegm-turbidity syndrome

Authors: Shu-Ning Liu, Xin Ping, Shao-Kun Qin, Ye Lu, Shao-Dan Zhang, Lin Pei
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Abstract

Through expounding the theory of phlegm-turbidity and the development of epilepsy, this paper presents the new theoretical basis for the treatment of epilepsy. The authors calculate that phlegm and turbidity are different in the formation and pathogenic effects. Therefore, it is necessary to expound the formation of the phlegm and turbidity. It is also necessary to explain the pathogenesis of the phlegm and turbidity in the epilepsy. Phlegm is caused by the invasion of external evil, emotional disorders, or Qi deficiency and decline, resulting in Qi and blood disorder in the body; the accumulation of phlegm and heat for a long time will lead to the accumulation of turbidity; further with the failure of Qi and fluid circulation, it will lead to brain damage and epileptic seizures. Therefore, the treatment needs to distinguish the severity of phlegm and turbidity, based on which, use different herbs for the treatment of epilepsy.

Keywords: Epilepsy, Phlegm-turbidity, Pathogenesis, Detoxification, Traditional Chinese medical treatment
Effects of mindfulness-based stress reduction therapy on anxiety and depression in patients with maintenance hemodialysis: a meta analysis

Effects of mindfulness-based stress reduction therapy on anxiety and depression in patients with maintenance hemodialysis: a meta analysis

Authors: Xiao-Xiao Yang, Yuan-Yuan Chen, Fan-Jie Meng
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Abstract

Objective: This study aimed to evaluate the effects of mindfulness-based stress reduction therapy on anxiety and depression in patients with maintenance hemodialysis. Methods: CNKI, VIP, WanFang, CBM, Embase, the Cochrane Library and PubMed databases were retrieved. Randomized controlled trials of intervention effects of mindfulness-based stress reduction combined with conventional hemodialysis education compared with conventional hemodialysis education on maintenance hemodialysis patients were collected. The retrieval period was from the establishment of the database to December 2019. Two researchers independently screened the literatures, extracted the data and evaluated the risk of bias in the included studies. RevMan 5.3 software was used for analysis. Results: A total of 9 studies, which comprised a total of 664 participants were included in the final meta analysis. The results showed that mindfulness-based stress reduction could reduce the anxiety of patients (SMD = −1.65, 95% CI: −2.29 to −1.01), reduce the depression (SMD = −1.44, 95% CI: −1.85 to −1.03). Conclusion: Mindfulness-based stress reduction therapy has positive effects on depression, anxiety in patients with maintenance hemodialysis.

Keywords: Mindfulness-based stress reduction, Maintenance hemodialysis, Depression, Anxiety, Meta-analysis
The inhibitory effects of Yigan Jiangzhi formula on hepatic metastasis of colorectal cancer

The inhibitory effects of Yigan Jiangzhi formula on hepatic metastasis of colorectal cancer

Authors: Yuan-hong Zhao, Qian-qian Niu, Quan-zheng Li, Ji-hong Yin, Yu Lu, Zheng Li
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Abstract

Background: To observe the inhibitory effects of Yigan Jiangzhi formula (liver-supplementing lipid-lowering formula, YGJZF) on hepatic metastasis of colorectal cancer. Methods: The hepatic metastasis BALB-c mice model of colorectal cancer was established by injecting HCT-116 cell suspension following splenectomy. Next, we randomly divided BALB-c mice into 5 groups, which were blank group, model group (tumor only), traditional Chinese medicine group (YGJZF), western medicine group (capecitabine), combined group (YGJZF and capecitabine), respectively. After 14 days treatment, the effects of different treatments were evaluated the serological indicators were evaluated, including the levels of alanine transaminase, aspartate transaminase, triglyceride, total cholesterol and vascular endothelial growth factor (VEGF) by ELISA. Results: Except the blank group, the other groups showed diffuse hepatic metastasis. Compared with the model group, the total number and weight of the metastatic tumors as well as serological indicators in medicine-given groups were sharply reduced (P < 0.05 for all) the combined group had better effects. The serum levels of these indicators showed no statistical difference among each medicine-given group (P > 0.05), but the combined group has a remarkable decrease of all the indicators than in western medicine group. Conclusion: YGJZF not only can inhibit the hepatic metastasis of colorectal cancer in BALB-c mice, but also affect the levels of hepatic enzymes and lipids. Meanwhile, it can reduce the expression of VEGF. All these results indicate that YGJZF, which lowers down lipids and protects hepatic functions, has the potential to block VEGF pathway, contributing to the inhibition of hepatic metastasis.

Keywords: Yigan Jiangzhi formula, Hepatic metastasis of colorectal cancer, Lifestyle, Vascular endothelial growth factor, Lipid-lowering
Antioxidative effect of peroxiredoxin-3 in the rat myocardium exposed to renal ischemia-reperfusion injury

Antioxidative effect of peroxiredoxin-3 in the rat myocardium exposed to renal ischemia-reperfusion injury

Authors: Xue-Bo Li, Xin Jin, Long Xu, Bo Hu, Guang-Tao Xu, De-Qing Chen
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Abstract

Background: Peroxiredoxin-3 (Prx-3) is known to be involved in the clearance of cellular hydrogen peroxide and plays an important role in protecting the myocardial tissue against damage of oxidative stress. However, the role of Prx-3 in protecting the myocardial tissue against renal ischemia/reperfusion (I/R)-induced myocardial injury (RI/RMI) remains unknown. We aimed to examine the antioxidative effect of Prx-3 using a rat RI/RMI model in an attempt to find a new approach to the prevention and treatment of myocardial injury induced by renal I/R. Methods: A RI/RMI rat model was established to detect the renal histopathology and renal functions by hematoxylin-eosin staining staining and commercially available assay kits. The myocardial antioxidant activity and the expressions of mRNA and protein of Prx-3 in the myocardial tissue were measured by real-time polymerase chain reaction and Western blotting assay, respectively. Results: Compared with the normal and control groups, the serum level of blood urea nitrogen and serum creatinine was significantly increased in the I/R group (P < 0.05). Histopathological changes in the kidneys were also more obvious, including glomerular cystic and renal interstitial hemorrhage, renal tubular epithelial cell edema, and tubular type formation. The mRNA and protein expressions of Prx-3 were increased significantly in the RI/MRI rat model as compared with those in the normal and control groups. Conclusion: Oxidative damage occurred in the remote myocardium after renal I/R and Prx-3 was able to enhance the self-regulatory ability of the myocardium against damage from oxidative stress after RI/MRI.

Keywords: Peroxiredoxin-3, Antioxidation, Renal ischemia/reperfusion-induced myocardial injury
Application of diffusion kurtosis imaging technology in evaluating early mild traumatic brain injury

Application of diffusion kurtosis imaging technology in evaluating early mild traumatic brain injury

Authors: Zhi-jie Zhang, Wei Liu, Guo-shi LV, Zheng Pan, Xiao-min Liu, Bo Wang
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Abstract

Objective To explore the value of magnetic resonance diffusion kurtosis imaging in diagnosing early tiny changes of brain tissue after mild traumatic brain injury. Methods A total of 22 patients with mild traumatic brain injury (study group) and 20 healthy subjects (control group) were enrolled in this study, and diffusion kurtosis imaging magnetic resonance scanning was employed in all subjects. fractional anisotropy, fractional anisotropy of kurtosis, mean kurtosis, axial kurtosis and radial kurtosis of diffusion kurtosis imaging parameters in the genu of corpus callosum, splenium corporis callosi, internal capsule, thalamus, putamen, cortex of frontal lobe, temporal lobe and parietal lobe at control group, the injured side and the mirror regions were measured, and the results were compared between the two groups. The receiver operating characteristic curve was used to evaluate the ability of different parameters in diagnosing mild traumatic brain injury. Results Compared with the control group, in the study group fractional anisotropy values of bilateral genu of corpus callosum, splenium corporis callosi, internal capsule and thalamus were significantly reduced, and fractional anisotropy of kurtosis values of bilateral thalamus and putamen were significantly reduced, and the differences were statistically significant (P<0.05). Compared with the control group, in the study group mean kurtosis and axial kurtosis values of bilateral genu of corpus callosum, posterior limb of Internal capsule, thalamus, putamen and cortex of temporal lobe were significantly reduced, while radial kurtosis values in the genu of corpus callosum, thalamus, cortex of frontal lobe, temporal lobe at the injured side were increased, and the differences were statistically significant (P < 0.05). Conclusion DKI techniques can sensitively detect the early tiny pathologic changes of cerebral tissue in mild traumatic brain injury patients, which provide more imaging evidence for the clinical early diagnosis treatment and prognosis.

Keywords: Mild traumatic brain injury, Magnetic resonance imaging, Diffusion kurtosis imaging

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