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Welcome to GMJ Medicine; The Official Medical Journal of the International Center for Intelligent Research (GMJ Medical Press, LLC, Germany)

Authors: Nanuli Doreulee

Welcome to GMJ Medicine; The Official Medical Journal of the International... 2018/Dec/28

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Abstract

GMJ Medicine is a continuous open access, online, peer reviewed journal owned and published by GMJ Medical Press, LLC in Germany from September, 2017. GMJ Medicine dedicated to publish good quality of research work in all areas of basic and clinical medicine. We will be published manuscript with new and interesting topics in the journal. Another of our goals is to increase scientific productivity in the fields of medical and health sciences. All research articles submitted to GMJ Medicine should be original in nature, never previously published in any journal or presented in a conference or undergoing such process across the globe. All the submissions will be peer-reviewed by the panel of experts associated with particular field. Submitted papers should meet the internationally accepted criteria and manuscripts should follow the style of the journal for the purpose of both reviewing and editing. The ethical policy of GMJ Medicine is based on the Committee on Publication Ethics (COPE) guidelines and complies with International Committee of Medical Journal Editors (ICMJE) codes of conduct. The following guidelines should be read in line with the journal’s guide for authors. The statements confirm that confidentiality and fairness should be considered in all the GMJ Medicine procedures and interactions. Readers, authors, reviewers and editors should follow these ethical policies once working with GMJ Medicine. We are delighted to welcome all authors to the first issue of "GMJ Medicine". The publication frequency of GMJ Medicine is continuous. All articles will be published immediately after acceptance under one VOLUME annually.

Keywords: GMJ Medicine, Continuous open access, Peer reviewed, GMJ Medical Press, Germany

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The Effect of Cigarette Smoking on Lung Capacity in Active, Previous, and Passive student smokers

Authors: Danil Hammoudi, Adekunle Sanyaolu, Dina Adofo, Ivan Antoine

The Effect of Cigarette Smoking on Lung Capacity in Active, Previous, and P... 2018/Dec/28

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Abstract

Background: Cigarette smoke predisposes a person to a lot of preventable diseases; this study aimed at comparing Lung Function in active, previous and non-smokers in students using the ratio of Forced Vital Capacity, to Forced Expiratory Volume measurement in one second called the Tiffeneau-Pinelli Index. Methods: A cross-section of 77 students from the St. James School of Medicine, Anguilla campus in the Caribbean who are active smokers, previous smokers or non-smokers were randomly sampled with consent using questionnaire based study and measurement of FEV/FVC ratio was done. Result: The results showed that the mean FEV/FVC ratio for Smokers was lower than that for non-smokers and Ex-smokers in both test 1 and 2. The FEV/FVC ratio by sex was higher in females for both test 1 and 2. There were significant differences among the races with Caucasians having the lowest mean value of 86.04 and 85.88 for test 1 and 2 respectively. Higher ratio of more than 0.7 for smokers, ex-smokers and non-smokers was recorded for mean FEV/FVC ratio. Conclusion: The FEV/FVC ratio was lower in smokers compared to non-smokers and Ex-smokers though not statistically significant.

Keywords: FEV/FVC, Ex-smokers, Smokers, Non-smokers, Test

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Oral Administration of Menthol Alleviate Adverse Effects of Polycystic Ovarian Syndrome in Blood Biochemical Parameters and Antioxidant Status in Wister Rats.

Authors: Behzad Mesbahzadeh, Mahshid Garmsiri, Faranak Jalalvand, Layla Shojaie, Muhammad Azam Kakar

Oral Administration of Menthol Alleviate Adverse Effects of Polycystic Ovar... 2018/Dec/28

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Abstract

Background: Polycystic ovarian syndrome (PCOS) has been related to dyslipidemia and suppression of antioxidant status. Howeverl, novel agents such as menthol can be an efficient strategy for alleviation of PCOS. This study was conducted to evaluate the effects of different levels of menthol in blood biochemical parameters and antioxidant status in Wistar rats induced with PCOS. Methods: Fifty Wistar rats were used in this study and the animals divided into five groups including; 1) Control group (Control) or healthy rats, 2) PCOS group (PCOS) that did not receive any menthol, 3, 4 & 5) Animals that received 2, 4 and 6 mg/kg of body weight (PCOS-2, PCOS-4 and PCOS-6). To induce the PCOS, 5 mg estradiol valerate was administrated. At the end of the trial session, blood samples were taken to evaluate plasma concentrations of glucose, insulin, total cholesterol, triglycerides, HDL-C, LDL-C, ferric-reducing ability of plasma (FRAP), advanced oxidation protein product (AOPP) and total oxidation status (TOS). Results: Induction of PCOS increased glucose, insulin, total cholesterol, triglycerides, LDL-C, FRAP, AOPP and TOS, and decrease HDL-C. The use of menthol especially in higher levels improved the mentioned parameters. PCOS also increased body weight and oral treatment of menthol helped to maintain the body weight. Conclusion: It is concluded that menthol improved antioxidant status in rats with PCOS. Thus, use of menthol is recommended for treatment of PCOS.

Keywords: Glucose, Lipid profile, Oxidation, PCOS, Rat

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Carvacrol Alleivated Negative Effects of Diabetes on Inflammation and Oxidation by Modulation in Gene Expression of Inflammatory and Antioxidant System in Diabetic Rat Model

Authors: Seyed Ashkan Tabibzadeh Dezfuli, Mohanna Ehsani, Omid Lakzaei Azar

Carvacrol Alleivated Negative Effects of Diabetes on Inflammation and Oxida... 2018/Dec/28

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Abstract

Background: Diabetes has been known as a prevalence disorder and the use of common drugs has been faced many issues with multiple limitations. This study aimed to evaluate the use of carvacrol, as a novel agent, for treatment of diabetes. Methods: A single dose of streptozotocin (55mg/kg body weight) was used to induce the diabetes in rats. The animals were grouped into five groups including 1) Control healthy animals, 2) Diabetic controls, 3, 4 & 5) Diabetic animals given carvacrol (5, 10 and 15 mg/kg body weight/day) in neutral sterile olive oil solution oral gavage, respectively. The levels of malondialdehyde (MDA) and catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities were evaluated. The levels of IL-1β, IL-6 and TNF-α expression in liver were assessed. Results: Administration of streptozotocin increased levels of MDA, IL-1β, IL-6 and TNF-α and also decreased activities of catalase, SOD and GPX (P<0.05). Oral administration of carvacrol, especially 15 mg/kg body weight/day, could decrease levels of MDA, IL-1β, IL-6 and TNF-α and also increase activities of catalase, SOD and GPX in comparison to diabetic control (P<0.05). Conclusion: Carvacrol could decrease or alleviate the negative effects of carvacrol on inflammation and antioxidant status that could be attributed to antioxidant properties. It could be recommended to apply carvacrol in commercial prescription in combination with other agents or as a single agent for treatment of diabetes.

Keywords: Antioxidant enzymes, Diabetes, Pro-inflammatory cytokines

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Modulation of 6-gingerolin Antidepressant-like Effects: An Investigation of Serotonergic System in Mice Model

Authors: Saman Sedighi, Bahram Nasiri, Reza Alipoor, Nasrollah Moradi-kor

Modulation of 6-gingerolin Antidepressant-like Effects: An Investigation of... 2018/Dec/28

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Abstract

Background: It has been reported that ginger is involved in serotonergic system. It seems that ginger effect could be attributed to its active compound or gingerol. The present study was conducted to evaluate the effects of gingerol on antidepressant-like effects by investigation of serotonergic system in mice model. Methods: Following pilot study and selection of doses, mice were divided into 4 groups. Receptor antagonists were injected, gingerol was administrated and a trial suspension test was conducted. Results: Administration of gingerol could induce antidepressant-like effect (P<0.001), without induction of changes in spontaneous locomotor activity in the open-field test. Pretreatment of mice with pCPA (preventor of serotonin synthesis), WAY100135 (receptor antagonist), ketanserin (5HT2A receptor antagonist), and cyproheptadine (5HT2 receptor antagonist) prevented the antidepressant-like effect induced by the gingerol (P<0.05). Conclusion: It could be stated that gingerol is involved in antidepressant-like effects through serotonergic system in mice model. It could be recommended to use the gingerol in commercial preparations for prescription as an antidepressant agent.

Keywords: Antidepressant-like, Gingerol, Mouse model, Serotonin pathway