When Assay Format Matters: a Case Study on the Evaluation of Three Assay Formats to Support a Clinical Pharmacokinetic Study Journal title: The AAPS Journal Authors: Kun Peng, Dana Baker, Suzanne Brignoli, Janis Cabuhat, Saloumeh K. Fischer Subject(s): Medicine
Mechanism-Based Pharmacokinetic Modeling to Evaluate Transporter-Enzyme Interplay in Drug Interactions and Pharmacogenetics of Glyburide Journal title: The AAPS Journal Authors: Manthena V. S. Varma, Renato J. Scialis, Jian Lin, Yi-An Bi, Charles J. Rotter, Theunis C. Goosen, X... Subject(s): Medicine
Mechanistic Modeling of Monocarboxylate Transporter-Mediated Toxicokinetic/Toxicodynamic Interactions Between γ-Hydroxybutyrate and l -Lactate Journal title: The AAPS Journal Authors: Bridget L. Morse, Nisha Vijay, Marilyn E. Morris Subject(s): Medicine
Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define the In Vitro Drug Release Profile Journal title: The AAPS Journal Authors: Shuo Yang, Xianzhen Yin, Caifen Wang, Haiyan Li, You He, Tiqiao Xiao, Lixin Sun, Jiasheng Li, Peter... Subject(s): Medicine
Systematic Verification of Bioanalytical Similarity Between a Biosimilar and a Reference Biotherapeutic: Committee Recommendations for the Development and Validation of a Single Ligand-Binding Assay to Support Pharmacokinetic Assessments Journal title: The AAPS Journal Authors: Joseph C. Marini, Michael Anderson, Xiao-Yan Cai, John Chappell, Todd Coffey, Dominique Gouty, Aparn... Subject(s): Medicine
Similarities and Differences in Gastrointestinal Physiology Between Neonates and Adults: a Physiologically Based Pharmacokinetic Modeling Perspective Journal title: The AAPS Journal Authors: Guo Yu, Qing-Shan Zheng, Guo-Fu Li Subject(s): Medicine
Population Pharmacokinetic/Pharmacodynamic Modeling of Guanfacine Effects on QTc and Heart Rate in Pediatric Patients Journal title: The AAPS Journal Authors: William Knebel, James Ermer, Jaideep Purkayastha, Patrick Martin, Marc R. Gastonguay Subject(s): Medicine
Reliability and Extension of Quantitative Prediction of CYP3A4-Mediated Drug Interactions Based on Clinical Data Journal title: The AAPS Journal Authors: Constance Loue, Michel Tod Subject(s): Medicine
Elucidation of Arctigenin Pharmacokinetics After Intravenous and Oral Administrations in Rats: Integration of In Vitro and In Vivo Findings via Semi-mechanistic Pharmacokinetic Modeling Journal title: The AAPS Journal Authors: Qiong Gao, Yufeng Zhang, Siukwan Wo, Zhong Zuo Subject(s): Medicine
Evaluation of Acoustic Membrane Microparticle (AMMP) Technology for a Sensitive Ligand Binding Assay to Support Pharmacokinetic Determinations of a Biotherapeutic Journal title: The AAPS Journal Authors: Shannon D. Chilewski, W. Matthew Dickerson, Johanna R. Mora, Ashley Saab, Edward M. Alderman Subject(s): Medicine
Study Reanalysis Using a Mechanism-Based Pharmacokinetic/Pharmacodynamic Model of Pramlintide in Subjects with Type 1 Diabetes Journal title: The AAPS Journal Authors: Jing Fang, Cornelia B. Landersdorfer, Brenda Cirincione, William J. Jusko Subject(s): Medicine
Stratification of Antibody-Positive Subjects by Antibody Level Reveals an Impact of Immunogenicity on Pharmacokinetics Journal title: The AAPS Journal Authors: Lei Zhou, Sarah A. Hoofring, Yu Wu, Thuy Vu, Peiming Ma, Steven J. Swanson, Narendra Chirmule, Marta... Subject(s): Medicine
Specific Method Validation and Sample Analysis Approaches for Biocomparability Studies of Denosumab Addressing Method and Manufacture Site Changes Journal title: The AAPS Journal Authors: Ramak Pourvasei, Ed Lee, Michael Eschenberg, Vimal Patel, Chris Macaraeg, Kinnari Pandya, Judy Shih,... Subject(s): Medicine
Determination of the Dominant Arachidonic Acid Cytochrome P450 Monooxygenases in Rat Heart, Lung, Kidney, and Liver: Protein Expression and Metabolite Kinetics Journal title: The AAPS Journal Authors: Ahmed A. El-Sherbeni, Mona E. Aboutabl, Beshay N. M. Zordoky, Anwar Anwar-Mohamed, Ayman O. S. El-Ka... Subject(s): Medicine
A Pharmacokinetic Simulation Tool for Inhaled Corticosteroids Journal title: The AAPS Journal Authors: Benjamin Weber, Guenther Hochhaus Subject(s): Medicine
