A One-Step Solid Phase Extraction Method for Bioanalysis of a Phosphorothioate Oligonucleotide and Its 3′ n-1 Metabolite from Rat Plasma by uHPLC–MS/MS Journal title: The AAPS Journal Authors: Buyun Chen, Michael Bartlett Subject(s): Medicine
Metabolism of GTI-2040, a phosphorothioate oligonucleotide antisense, using ion-pair reversed phase high performance liquid chromatography (HPLC) coupled with electrospray ion-trap mass spectrometry Journal title: The AAPS Journal Authors: Xiaohui Wei, Guowei Dai, Zhongfa Liu, Hao Cheng, Zhiliang Xie, Guido Marcucci, Kenneth K. Chan Subject(s): Medicine