A Semi-mechanistic Model for the Effects of a Novel Glucagon Receptor Antagonist on Glucagon and the Interaction Between Glucose, Glucagon, and Insulin Applied to Adaptive Phase II Design Journal title: The AAPS Journal Authors: Joanna Z. Peng, William S. Denney, Bret J. Musser, Rong Liu, Kuenhi Tsai, Lanyan Fang, Marc L. Reitm... Subject(s): Medicine
The Liver X Receptor Agonist T0901317 Protects Mice from High Fat Diet-Induced Obesity and Insulin Resistance Journal title: The AAPS Journal Authors: Mingming Gao, Dexi Liu Subject(s): Medicine
Cannabinoid receptors and endocannabinoids: Evidence for new players Journal title: The AAPS Journal Authors: Ken Mackie, Nephi Stella Subject(s): Medicine
Modulating inhibitory ligand-gated ion channels Journal title: The AAPS Journal Authors: Michael Cascio Subject(s): Medicine
In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands Journal title: The AAPS Journal Authors: Richard A. Houghten, Colette T. Dooley, Jon R. Appel Subject(s): Medicine
Targeting the PDZ domains of molecular scaffolds of transmembrane ion channels Journal title: The AAPS Journal Authors: Andrea Piserchio, Mark Spaller, Dale F. Mierke Subject(s): Medicine
New paradigms and tools in drug design for pain and addiction Journal title: The AAPS Journal Authors: Victor J. Hruby, Frank Porreca, Henry I. Yamamura, Gordon Tollin, Richard S. Agnes, Yeon Sun Lee, Mi... Subject(s): Medicine
Conformational characteristics of the interaction of SR141716A with the CB1 cannabinoid receptor as determined through the use of conformationally constrained analogs Journal title: The AAPS Journal Authors: Brian F. Thomas, Yanan Zhang, Marcus Brackeen, Kevin M. Page, S. Wayne Mascarella, Herbert H. Seltzm... Subject(s): Medicine
Geldanamycin, an inhibitor of Hsp90, Blocks cytoplasmic retention of progesterone receptors and glucocorticoid receptors via their respective ligand binding domains Journal title: The AAPS Journal Authors: Mudit Kakar, Charu Kanwal, J. Rian Davis, Henan Li, Carol S. Lim Subject(s): Medicine
Optimizing targeted gene delivery: Chemical modification of viral vectors and synthesis of artificial virus vector systems Journal title: The AAPS Journal Authors: Sabine Boeckle, Ernst Wagner Subject(s): Medicine
Small-molecule agonists and antagonists of the opioid receptor-like receptor (ORL1, NOP): Ligand-based analysis of structural factors influencing intrinsic activity at NOP Journal title: The AAPS Journal Authors: Nurulain Zaveri, Faming Jiang, Cris Olsen, Willma Polgar, Lawrence Toll Subject(s): Medicine
Introduction of unsaturation into theN-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: Effect on affinity and selectivity Journal title: The AAPS Journal Authors: Sangeetha P. Sumithran, Peter A. Crooks, Rui Xu, Jun Zhu, Agripina G. Deaciuc, Lincoln H. Wilkins, L... Subject(s): Medicine
Homology modeling of opioid receptor-ligand complexes using experimental constraints Journal title: The AAPS Journal Authors: Irina D. Pogozheva, Magdalena J. Przydzial, Henry I. Mosberg Subject(s): Medicine
The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids Journal title: The AAPS Journal Authors: Roger G. Pertwee Subject(s): Medicine
Molecular modeling of mono- and bis-quaternary ammonium salts as ligands at the α4β2 nicotinic acetylcholine receptor subtype using nonlinear techniques Journal title: The AAPS Journal Authors: Joshua T. Ayers, Aaron Clauset, Jeffrey D. Schmitt, Linda P. Dwoskin, Peter A. Crooks Subject(s): Medicine