STUDY ON DISSOLUTION IMPROVEMENT OF ALLOPURINOL BY CO-GRINDING AND FUSION METHOD USING SOLID DISPERSION TECHNIQUE
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 3
Abstract
Allopurinol is a commonly used drug in the treatment of chronic gout or hyperuricaemia associated with treatment of diureticconditions. One of the major problems with the drug is that it is practically insoluble in water, which results in poorbioavailability after oral administration. In the present study, solid dispersions of allopurinol (allo) were prepared by cogrindingmethod and melting methods to increase its water solubility. Hydrophilic carriers such as polyvinylpyrrolidone,polyethylene glycol 6000 were used in the ratio of 1:1, 1:2 and 1:4 (drug to carrier ratio). The aqueous solubility of allopurinolwas favored by the presence of both polymers. These new formulations were characterized in the liquid state by phasesolubility studies and in the solid state by UV spectroscopy. Solid state characterizations indicated that allopurinol was presentas an amorphous material and entrapped in polymer matrix. In contrast to the very slow dissolution rate of pure allopurinol,the dispersion of the drug in the polymers considerably enhanced the dissolution rate. Solid dispersion prepared withKollicoat IR showed highest improvement in wettability and dissolution rate of allopurinol. Therefore, the present studyshowed that kollicoat IR has a significant solubilizing effect on allopurinolKEYWORDS: Allopurinol, polyethylene glycol 6000, solid dispersions, closed melting method, dissolutionenhancement.
Authors and Affiliations
Fayjunessa Runa| World University of Bangladesh(WUB). Department of Pharmacy. Dhaka. Bangladesh., Md. Raihan Sarkar| World University of Bangladesh(WUB). Department of Pharmacy. Dhaka. Bangladesh., Razia Sultana| World University of Bangladesh(WUB). Department of Pharmacy. Dhaka. Bangladesh., Khurshid Jahan| World University of Bangladesh(WUB). Department of Pharmacy. Dhaka. Bangladesh., Zubair Khalid Labu*| World University of Bangladesh(WUB). Department of Pharmacy. Dhaka. Bangladesh.
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