DEVELOPMENT AND EVALUATION OF FAST DISSOLVING THIN FILMS OF ARIPIPRAZOLE
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 5
Abstract
In the current pharmaceutical research fast dissolving films are playing an important role. In the present research, five different rapidly dissolving films of Aripiprazole were prepared successfully by using different polymer such as hydroxypropyl methyl cellulose (HPMC-E5 LV), polyvinyl pyrollidone by means of solvent casting method. Citric acid as saliva stimulating agent, mannitol as sweetening agent and menthol was used as flavoring agent. Aripiprazole, is an atypical antipsychotic. It is recommended and primarily used in the treatment of schizophrenia and bipolar disorder. The prepared films were evaluated for different parameters including thickness, mass uniformity, pH, folding endurance, drug content uniformity, cumulative percent release, in-vitro dissolution test and accelerated stability studies. In-vitro dissolution studies were performed dissolution guidelines for about 30 minutes. For analyzing the mechanism of drug release kinetics of the films, the data obtained were fitted to various kinetic equations of zero order, first order, Higuchi model and Korsmeyer-Peppas model. On the basis of different evaluated parameters formulation of batch F4 was found to be optimum formulation. The optimized formulation F4 was evaluated for the stability studies at 400 C, 75% RH for 45 days. From the evaluation, it was found that there is no significant change in appearance, pH, folding endurance, drug content, in vitro disintegration and percentage drug release.
Authors and Affiliations
Edenta Chidi, Nwobodo Ndubuisi Nwobodo, Offiah Raymond O
Keywords
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- EP ID EP36413
- DOI https://doi.org/10.22270/ujpr.v2i5.R5
- Views 306
- Downloads 0
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