DESIGN AND EVALUATION OF CHRONOTHERAPEUTIC PULSATILE DRUG DELIVERY SYSTEM OF CILNIDIPINE
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 5
Abstract
At present scenario the drug regimen based on circadian rhythm is recently gaining much attention worldwide by researchers. Justification behind it is that, there are various diseases like asthma, hypertension, and arthritis show circadian variation that demand time scheduled drug release for effective drug action. A chronodelivery system, based on biological rhythms, is a state-of the- art technology for drug delivery. The aim of present work is formulate and evaluate a press coated pulsatile release tablets of Cilnidipine using an admixture of hydrophilic polymer i.e. hydroxypropyl methyl cellulose (HPMC) and pH sensitive polymers (ethyl cellulose, eudragit S-100) in order to achieve a predetermined lag time for chronopharmacotherapy of Hypertension. Cilnidipine is the novel calcium antagonist accompanied with L-type and N-type calcium channel blocking function used for the treatment of hypertension. The tablets prepared were evaluated for different properties like bulk density, tapped density, Angle of repose and Carr’s index), hardness, thickness, weight variation, friability, drug content uniformity and in vitro drug release study.
Authors and Affiliations
Nweje-Anyalowu Paul C, Anyalogbu Ernest A A, White Alalibo Jim
Keywords
Related Articles
- EP ID EP36412
- DOI https://doi.org/10.22270/ujpr.v2i5.R4
- Views 326
- Downloads 0
ABACAVIR LOADED NANOPARTICLES: PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN VITRO EVALUATION
The present study deals with the formulation and evaluation of Abacavir nanoparticles. Abacavir is an anti-retroviral drug; it is used in treatment of AIDS. Abacavir nanoparticles were formulated by solvent displacement...
AN UPDATED REVIEW ON TRANSFERSOMES: A NOVEL VESICULAR SYSTEM FOR TRANSDERMAL DRUG DELIVERY
Transdermal route is an interesting option in this respect because a transdermal route is convenient and safe, avoid first pass metabolism, predictable and extended duration of activity, minimizing undesirable side effec...
EXAMINING THE IMPACT OF ACCESS TO HEALTHCARE INFORMATION IN PROVIDING SERVICE IN HOSPITAL LEVEL OF HORMOZGAN PROVINCE
Examining the impact of access to healthcare information in providing service in hospital level was performed in Hormozgan province. The study is applied in objective respect. The statistical population of this study inc...
DEVELOPMENT AND CHARACTERIZATION OF DIRECT COMPRESSED MATRIX MINI TABLETS OF NAPROXEN SODIUM
The present study was carried out to formulate and evaluate multiparticulate system containing mini-tablets of Naproxen sodium. Naproxen is a nonsteroidal anti-inflammatory drug (NSAIDs) with analgesic and antipyretic pr...
EFFECTS OF EMODIN ON BLOOD GLUCOSE AND BODY WEIGHT IN TYPE 1 DIABETIC RATS
Objective of present study was to analyze the effect of emodin on blood glucose and body weight in rats with type 1 diabetes. A total of 45 healthy SD rats were selected followed by being adaptively fed for one week and...