EFFECTS OF EMODIN ON BLOOD GLUCOSE AND BODY WEIGHT IN TYPE 1 DIABETIC RATS
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 4
Abstract
Objective of present study was to analyze the effect of emodin on blood glucose and body weight in rats with type 1 diabetes. A total of 45 healthy SD rats were selected followed by being adaptively fed for one week and then from them 15 rats were randomly selected out as the control group and the remaining 30 healthy SD rats were given intraperitoneal injection of streptozotocin to establish diabetic model with the control group receiving intraperitoneal injection of citrate buffer solution of same doses; At the fifth day, the rats were fasted for 6h and appropriately fed with water. Then the tail blood was collected to measure the fasting blood glucose of rats and this step was repeated 15 days after the injection of streptozotocin. The diabetic rat model was established successfully when the blood glucose was detected to be no less than 16.9mmol/L; thirty diabetic model rats were randomly divided into diabetes group and emodin group with 15 cases in each group (n = 15); 15 days later, the rats in diabetes group and control group were treated with intragastric administration of PBS, 5ml/kg, and the rats in emodin group were given intragastric administration of emodin suspension (8g/L), 5ml/kg. The changes of fasting blood glucose and body weight were observed and compared in three groups from the time point of before model establishment to fifth and fifteenth days after successful establishment of model. There was no significant difference among three groups in fasting blood glucose and body weight at the initial stage of establishing model; In diabetes group and emodin group, the rat’s body weight in T2 was significantly lower than that in T1 with the body weight decreasing more significantly in diabetes group (P<0.05), while the blood glucose in T2 was significantly higher than that in T1 with the blood glucose increasing more significantly in diabetes group (P<0.05). Emodin can relieve hyperglycemia in type I diabetic rats but has little influence on body weight.
Authors and Affiliations
Kaijian Hou, Chao Chen, Xuhuang Wang, Yuanyuan Guo
Keywords
Related Articles
- EP ID EP36399
- DOI https://doi.org/10.22270/ujpr.v2i4.R3
- Views 285
- Downloads 0
SERO-PREVALENCE OF HEPATITIS C VIRUS AMONG DENTAL CLINIC WORKERS IN SANA’A CITY- YEMEN AND THE RISK FACTORS CONTRIBUTING FOR ITS INFECTION
Dental clinic workers (DCWs) in Yemen have an additional risk of getting infected with HCV from their work place and till now there is no study in prevalence of HCV infection and associated risk factors among DCWs. The p...
EVALUATION OF THE IMMUNE RESPONSE TO POLIO VACCINE IN MALNOURISHED CHILDREN IN SANA'A CITY
This study was made to evaluate the immune response to polio virus vaccine among PEM children by measuring the level of circulating Immunoglobulin G (IgG) antibodies against polio virus (IgG-PV) after immunization with t...
PREVALENCE OF LEPTOSPIROSIS AMONGST SLAUGHTERHOUSE WORKERS AND BUTCHERS IN SANA'A CITY-YEMEN
Zoonotic infections can be work-related risks to people who labor in nearby connection with animals. The goals of present study were to find out the prevalence of leptospira antibodies and impact factors of leptospirosis...
ETIOLOGY AND RISK FACTORS OF STOMATITIS AMONG YEMENI DENTURE WEARERS
Denture stomatitis (DS) is a benign condition, usually asymptomatic, that can affect denture wearers patients. The aims of this study was to describe the etiology of DS among Yemeni denture wearers and the risk factors...
THE ASSOCIATION OF ADULT MALE AND FEMALE INFERTILITY WITH CELIAC DISEASE PATIENTS IN YEMEN
Celiac disease’s potentially destructive effect on reproductive health is among the most vital matters associated with progress awareness. Men and women with unexplained infertility, women with recurrent abortions, intra...