HYPOGLYCEMIC AND LIPID LOWERING EFFECT OF AQUEOUS FRESH LEAF EXTRACT OF CHROMOLAENA ODORATA (LINN) IN ALBINO WISTAR RATS FED DIFFERENT CONCENTRATIONS OF CHOLESTEROL ENRICHED DIET
Journal Title: Universal Journal of Pharmaceutical Research - Year 2018, Vol 3, Issue 1
Abstract
High lipids and carbohydrate have been seriously implicated to cardiovascular problems, which has led to several uses of medicinal plants for traditional remedies. The present study investigated the lipid lowering activity of fresh leaf extract of Chromolaena odorata in Albino wistar rats. Twenty (20) rats used for the study were grouped into four groups of five (5) rats each. Group I served as normal control, group II, III and IV served as test groups, fed 75, 108 and 148 g of cholesterol enriched diet for one week and thereafter, administered with 50, 100 and 150 mg/kg body weight of fresh leaf extract of Chromolaena odorata respectively for four (4) days. Lipid profile and blood glucose were assayed at fed state and after administration. Results showed a significant (p<0.05) increase in total cholesterol, triacylglycerol, low density lipoprotein, blood glucose concentration and body weight compared with control group in fed state. Administration with fresh leaf extract of Chromolaena odorata showed a significant (p<0.05) increase in high density lipoprotein, significant (p<0.05) decrease in blood glucose concentration, low density lipoproteins, triacylglycerol, total cholesterol and body weight of rats. The oral treatment with 50, 100 and 150 mg/kg body weight of the fresh leaf extract of this study demonstrated a general hypoglycemic and hypolipidemic activity not necessary a dose dependent pattern. It may therefore be concluded that the hypoglycemic and hypolipidemic activity of Chromolaena odorata taken freshly squeezed could be due to its phytochemical and antioxidants content.
Authors and Affiliations
Idoko A, Ikpe VPO, Rita ON, Nelson NO, Effiong JU, Alhassan AJ, Muhammad IU, Abubakar N, Abubakar SM, Ugwudike PO
Keywords
Related Articles
- EP ID EP36441
- DOI https://doi.org/10.22270/ujpr.v3i1.R7
- Views 316
- Downloads 0
FORMULATION AND EVALUATION OF METOCLOPRAMIDE HCL RECTAL SUPPOSITORIES
Metoclopramide hydrochloride is a dopamine receptor antagonist, used mostly for stomach and esophageal problems as it is a prokinetic agent. The aim of the present study was to design and evaluate the suppositories of Me...
THE EFFECT OF TRAFFIC FACTORS AND TECHNOLOGY FACTORS ON CHRONOLOGICAL DELAY OF EMERGENCY (115) ON THE BESIDES OF INJURED PEOPLE IN BOYER AHMAD CITY IN 2017
The aim of this study is to investigate traffic factors and technology factors on chronological delay of emergency (115) on the besides of injured people in Boyer Ahmad city in 2017. The research method of this investiga...
ABACAVIR LOADED NANOPARTICLES: PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN VITRO EVALUATION
The present study deals with the formulation and evaluation of Abacavir nanoparticles. Abacavir is an anti-retroviral drug; it is used in treatment of AIDS. Abacavir nanoparticles were formulated by solvent displacement...
THE ROLE OF DIGITAL MARKETING IN MEDICAL TOURISM INDUSTRY IN POINT OF VIEW OF MEDICAL TOURISM POLICY MAKERS OF SHIRAZ IN 2017
Medical tourism refers to traveling to places where the individual could use medical services. Therefore, such a travel requires various activities in any of which the individual health is considered. Main samples of the...
ORAL C.ALBICANS COLONIZATION AND NON-CANDIDA ALBICANS CANDIDA COLONIZATION AMONG UNIVERSITY STUDENTS, YEMEN
Candida albicans is diploid yeast that in some circumstances may cause oral or oropharyngeal infections. This investigation aimed to study the oral C. albicans colonization (OCC) and Non-Candida albicans Candida coloniza...