1,2-Dichloroethane. Documentation of suggested occupational exposure limits (OELs)
Journal Title: Podstawy i Metody Oceny Środowiska Pracy - Year 2014, Vol 30, Issue 4
Abstract
1,2-Dichloroethane is a colorless liquid with an odor typical of chlorinated hydrocarbons. 1,2- -Dichloroethane has been used as an inter-mediate in the manufacture of vinyl chloride; as a scavenger in leaded gasoline; and a solvent. It is also used in paint removers, wetting and penetrating agents, ore flotation, and soaps and scouring compounds. Animal studies have uniformly indicated liver and kidney injury from exposure to 1,2-dichloroethane. 1,2-Dichloroethane vapor is irritating to the eyes, nose, throat (mucous membranes) and skin. Human exposure to 1,2-dichloroethane results in CNS depression. This paper reports symp-toms such as nausea, vomiting, and dizziness. 1,2-Dichloro-ethane has been classified by the International Agency for Research on Cancer as possibly carcinogenic to humans based on lim-ited human epidemiological data and sufficient animal toxicity (IARC category 2b). Under the classification and labelling legislation in Eu-rope it is classified as a carcinogen Cat. 1B. In-formation about the hazard from 1,2-dichloroethane is limited. Animal toxicity stud-ies have shown a range of tumors induced from ingested 1,2-dichloroethane. However, human epidemiological evidence for occupational exposure causing cancer is weak. There is no basis to identify a suitable risk estimate. To determine MAC value for 1,2-dichloroethane systemic effect was adopted as a critical effect. The Expert Group for Chemical Agents has recommended TWA of 10 mg/m3 and STEL of 20 mg/m3. It has been also proposed to label the substance with “I” (irritant), Skin (substance can penetrate skin) and a carcinogen Cat. 1B.
Authors and Affiliations
Renata Soćko
Keywords
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