(13) ANTIOXIDANT STATUS IN PERI-MENOPAUSAL AND POST-MENOPAUSAL WOMEN
Journal Title: Indian journal of applied basic medical sciences - Year 2014, Vol 16, Issue 22
Abstract
ABSTRACT BACKGROUND & OBJECTIVES: Menopause is a natural step in the process of ageing and free oxygen radicals have been proposed as important causative agents of ageing. The antioxidant system seems to be affected in post-menopausal women due to deficiency of estrogen, which is a powerful antioxidant. In view of this background, present study was carried out to find correlation between menopause and antioxidant status, if any. METHODS: Status of antioxidants was determined by spectrophotometric estimation of Superoxide Dismutase (SOD), and Ascorbic Acid in blood/serum of 105 women. The subjects consisted of 35 women of three distinct groups, namely, reproductive age, perimenopausal, and post-menopausal. Data obtained was analyzed by student’s t- test, ANOVA, and Pearson’s correlation coefficient (r). P < 0.05 was considered significant. RESULTS: Peri- and post-menopausal women exhibited significantly low erythrocyte SOD and serum ascorbic acid, as compared to the women of reproductive age. INTERPRETATION & CONCLUSION: Findings of this study corroborate the hypothesis that gradual loss of ovarian function is associated with a concomitant decrease in antioxidant status.”
Authors and Affiliations
Mamata Mahla, Varun Mahla
Keywords
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