Abulia: The Pathology of "Will" and Dopaminergic Dysfunction in Brain-Injured Patients

Abulia: The Pathology of "Will" and Dopaminergic Dysfunction in Brain-Injured Patients

Journal

Subject and more

  • LCC Subject Category: Biochemistry, Biomedicine, Medicine
  • Publisher's keywords: Abulia, motivation, rewards, dopamine, bromocriptine, functional recovery
  • Language of fulltext: english
  • Full-text formats available: PDF

AUTHORS

    Samir ALl-Adawi| College of Medicine, Sultan Qaboos University, P.O.Box 35, Al-Khod 123, Muscat, Sultanate of Oman. Institute of Psychiatry, Kings College, De Crespigny Park, Denmark Hill, London, UK. Regional Neurological Rehabilitation Unit, Homerton Hospital, Homerton Row, London, E9 6SR, U.K., J.H Powell| Department of Psychology, Goldsmiths College, University of London , Lewisham Way, New Cross, London, SE14 6 NW, U.K. Regional Neurological Rehabilitation Unit, Homerton Hospital, Homerton Row, London, E9 6SR, U.K. , S. Basavappa| Critical Care Research Laboratories, Harvard Medical School and Children s Hospital, Boston, MA02115, U.S.A, R.J. Greenwood| Regional Neurological Rehabilitation Unit, Homerton Hospital, Homerton Row, London, E9 6SR, U.K.

EDITORIAL INFORMATION

FULL TEXT

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ABSTRACT

The present paper describes a series of single-case evaluations of the effects of bromocriptine, a dopamine D2 post-synaptic receptor agonist in 13 patients with clinical features cf abulia. Method - An open trial in seven males and six females who had either traumatic brain injury or subarachnoid haemorrhage between two months and five years previously. After repeated baseline assessments, bromocriptine was administered in gradually increasing doses, Assessments were repeated at increasing doses, during maintenance, and after withdrawal. Same newly developed structured instruments for quantifying motivation were used; measures of anxiety and depression, and cognitive tests sensitive to motivation were also administered. Results- Following bromocriptine treatment improved on all scores measured other than mood. Improvement was maintained after bromocriptine withdrawal in nine of the patients. Conclusion- Abulia in patients with brain injury may result from dysfunction in the mesocorticolimbic dopaminergic cirucity, giving rise to associated deficiencies in reward responsiveness and cognitive function. New rating are propsed of motivation in brain injured patients.

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