Abulia: The Pathology of "Will" and Dopaminergic Dysfunction in Brain-Injured Patients

Apply

Abulia: The Pathology of "Will" and Dopaminergic Dysfunction in Brain-Injured Patients

Journal Title: Sultan Qaboos University Medical Journal - Year 1999, Vol 1, Issue 1

Abstract

The present paper describes a series of single-case evaluations of the effects of bromocriptine, a dopamine D2 post-synaptic receptor agonist in 13 patients with clinical features cf abulia. Method - An open trial in seven males and six females who had either traumatic brain injury or subarachnoid haemorrhage between two months and five years previously. After repeated baseline assessments, bromocriptine was administered in gradually increasing doses, Assessments were repeated at increasing doses, during maintenance, and after withdrawal. Same newly developed structured instruments for quantifying motivation were used; measures of anxiety and depression, and cognitive tests sensitive to motivation were also administered. Results- Following bromocriptine treatment improved on all scores measured other than mood. Improvement was maintained after bromocriptine withdrawal in nine of the patients. Conclusion- Abulia in patients with brain injury may result from dysfunction in the mesocorticolimbic dopaminergic cirucity, giving rise to associated deficiencies in reward responsiveness and cognitive function. New rating are propsed of motivation in brain injured patients.

Authors and Affiliations

Samir ALl-Adawi| College of Medicine, Sultan Qaboos University, P.O.Box 35, Al-Khod 123, Muscat, Sultanate of Oman. Institute of Psychiatry, Kings College, De Crespigny Park, Denmark Hill, London, UK. Regional Neurological Rehabilitation Unit, Homerton Hospital, Homerton Row, London, E9 6SR, U.K., J. H Powell| Department of Psychology, Goldsmiths College, University of London , Lewisham Way, New Cross, London, SE14 6 NW, U.K. Regional Neurological Rehabilitation Unit, Homerton Hospital, Homerton Row, London, E9 6SR, U.K. , S. Basavappa| Critical Care Research Laboratories, Harvard Medical School and Children s Hospital, Boston, MA02115, U.S.A, R. J. Greenwood| Regional Neurological Rehabilitation Unit, Homerton Hospital, Homerton Row, London, E9 6SR, U.K.

Keywords

Abulia motivation rewards dopamine bromocriptine functional recovery

Putting Research Findings into Clinical Practice Feasibility of integrated evidence-based care pathways in otorhinolaryngology head and neck surgery at Sultan Qaboos University Hospital, Oman

Objectives: A perception exists that clinicians in Oman are reluctant to adopt evidence-based practice (EBP). Tis pilot study was undertaken to study the feasibility of using EBP pathways at the point of care in otorhi...

EP ID EP13592
DOI -
Views 605
Downloads 23