1,4-Dichlorobenzene. Documentation of proposed values of occupational exposure limits (OELs)
Journal Title: Podstawy i Metody Oceny Środowiska Pracy - Year 2015, Vol 31, Issue 4
Abstract
1,4-Dichlorobenzene is a solid crystallinesubstance, colorless or white, with camphorlikeodour. It sublimes at room temperature. Itis used as insecticide (mainly in the mothballs),as a fumigant and as a component of indoordeodorants and air-fresheners used in dumpsters.1,4-Dichlorobenzene is used in the synthesis ofpolyphenylene sulfi de, 1,2,4-trichlorobenzene,2,5-dichloroaniline and dyes. It is also used inpharmaceutical industry.1,4-Dichlorobenzene is absorbed into the bodymainly by inhalation. It has low acute toxicity.Chronic effects in humans include irritation to eyesand mucous membranes of the upper respiratorytract, impaired lung function parameters, impairedkidney and liver function.In prolonged and chronic animal studies changeswere observed mainly in a liver. In male ratschanges were also observed in kidneys. Afterchronic exposure to 1,4-dichlorobenzene, changesdue to irritation were observed in epithelium of thenasal cavity.1,4-Dichlorobenzene has no signifi cant genotoxicpotential. Most in vitro and in vivo mutagenicitystudies were negative.1,4-Dichlorobenzene was carcinogenic to animals.Liver tumors were observed in the male and femalemice after oral administration of 1,4-dichlorobenzeneand after inhalation. The mechanism of liver tumorin mice after administration of 1,4-dichlorobenzeneby ingestion or inhalation is not exactly clearbut studies indicate the threshold nature of thiseffect. Adenocarcinomas of the renal tubule wereobserved in male rats after oral administration of1,4-dichlorobenzene. Specifi c genotoxic mechanism,irrelevant for humans, is responsible for kidneytumors in male rats exposed to 1,4-dichlorobenzene.1,4-Dichlorobenzene is not embryotoxic, teratogenicor fetotoxic. There was no impact on reproductivefunctions of animals in the two-generation study inrats exposed to 1,4-dichlorobenzene by ingestion orby inhalation.A critical effect for exposure to 1,4-dichlorobenzeneis hepatotoxic activity. Oral administration of1,4-dichlorobenzene (in capsules) in dogs for 52weeks caused changes in liver and NOAEL valueobtained from this study was 10 mg/kg/day.On the basis of this NOAEL value, after taking intoaccount uncertainty factors, the MAC (TWA) valueof 12 mg/m3 and STEL of 36 mg/m3 (3 times NDS)were recommended.There is no quantitative experimental data on skinabsorption of 1,4-dichlorobenzene, but on the basisof modeling data the “Skin” notation was addedbecause absorption of substances through the skincan be as important as inhalation. It is recommendedto label the substance with symbol “I” (irritant).
Authors and Affiliations
KATARZYNA KONIECZKO, SŁAWOMIR CZERCZAK
Keywords
Related Articles
- EP ID EP81609
- DOI -
- Views 108
- Downloads 0
1,2-Dichloroetan. Metoda oznaczania w powietrzu na stanowiskach pracy
1,2-Dichloroetan jest bezbarwną, wysoce łatwopalną cieczą o zapachu podobnym do chloroformu. Substancja ta jest stosowana w przemyśle jako półprodukt do produkcji chlorku winylu oraz innych chlorowanych węglowodorów. 1,2...
Petroleum mineral oils. Documentation
Petroleum mineral oils are vacuum distillation products of the crude oil residues obtained by distillation under normal pressure. In the processes of solvent-refined oils, catalytic hydro-genation or hydrocracking cause:...
Hydrazine. Determination in workplace air with high performance liquid chromatography – spectrophotometric technique
Anhydrous hydrazine in room temperature is colorless fuming oily liquid with ammonia-like odor. It is used in various industries for electrolytic plating of metals on glass and plastics, as a chemical intermediate for th...
Cisplatin. Determination in workplace air with high performance liquid chromatography
Cytostatic drugs are a specifi c group of chemotherapy drugs whose toxicity for patientsundergoing treatment is reasonably well understood. However, there is no data on theharmful effects of the impacts of these chemical...
1,2-Dimethoxyethane. Documentation of proposed values of occupational exposure limits (OELs)
1,2-Dimethoxyethane (EGDMA, ethylene glycol dimethyl ether, monoglym) belongs to the group of alkyl ether solvents. Under normal conditions, it is a colorless, volatile liquid with a faint odor of ether and is very solub...