Effect of Orange (Citrus sinensis) Peel Oil on Lipid Peroxidation, Catalase activity and Hepatic Biomarker levels in Blood Plasma of Normo Rats
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2012, Vol 1, Issue 1
Abstract
Dietary antioxidants are considered beneficial because of their potential protective role against oxidative stress, which is involved in the pathogenesis of multiple diseases such as cancer and coronary heart disease. The effect of feeding orange peel oil on lipid peroxidation, catalase and hepatic biomarkers in blood plasma of normo rats was investigated. Beside mouse chow, four diets were designed to contain 50% of energy as carbohydrate, 35% as fat, and 15% as protein, and one that was lipid-free diet which had distilled water substituted for fat. Groups of five rats were each fed one of these diets, while a fifth group was fed pelletized mouse chow. There was no significant difference in the amount of food consumed, though significant weight lost was observed in all groups except soybean oil. Feeding on orange peel oil led to significant (p<0.05) decrease in lipid peroxidation and catalase activities in comparison to soybean oil. Higher AST and lower ALT activities were observed in orange peel oil fed groups. These results suggest the oil from the orange peels possesses antioxidant potentials which could be protective against oxidative stress, thus useful in its treatment and management. However, the elevated levels of hepatic biomarkers pose a threat of hepatotoxicity thus suggesting that it should be consumed or used as a pharmaceutical ingredient at lower concentrations.
Authors and Affiliations
Ochuko L. Erukainure*| Food Technology Division, Federal Institute of Industrial Research, Lagos, Nigeria, John A. Ajiboye| College of Natural and Applied Sciences, Bells University of Technology, Ota, Nigeria, Florence F. Davis| College of Natural and Applied Sciences, Bells University of Technology, Ota, Nigeria, Kemisola Obabire| College of Natural and Applied Sciences, Bells University of Technology, Ota, Nigeria, Muhammad Aliyu| Departments of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
Keywords
Related Articles
- EP ID EP1494
- DOI -
- Views 610
- Downloads 31
PREPARATION AND ASSESSMENT OF AMORPHOUS SOLID DISPERSIONS USING VARIOUS METHODOLOGIES
Amorphous products and particularly amorphous solid dispersions are currently one of the most upcoming and widely used areas in the pharmaceutical field. This approach offers huge potential and advantageous features rega...
SYNTHESIS AND CHARACTERIZATION OF pH SENSITIVE PHARMACEUTICAL POLYMERS FOR CONTROLLED DRUG DELIVERY SYSTEMS.
The Pharmaceutical industry is evaluating modes of delivery for their prized therapeutics at every step of the design cycle. In recent years, pH dependent drug delivery systems have focused much for specific purposes. S...
SYNTHESIS AND CHARACTERIZATION OF SOME METAL COMPLEXES WITH IBA AS LIGAND DERIVED FROM 2–BENZOYLINDANE–1,3–DIONE
The present investigation are based on the synthesis and characterization of metal complexes with Schiff’s bases α– (1, 3– dioxo– indan– 2–yl) – benzylidene– aniline (IBA) derived from 2–Benzoylindane–1,3–Dione by cond...
H1N1 AND MOLECULAR DIAGNOSIS- RAPID AND EASE IN VIRAL AND DISEASE MONITORING
Influenza a viruses are medically significant pathogens responsible for higher mortality and morbidity throughoutthe world. Swine influenza known to be caused by influenza A subtypes H1N1, H1N2, H2N3,H3N1, and H3N2, is a...
Does Rottlerin or its congeners have a potential as adjuvant to antidote therapy of spider/snake venom intoxication?
Rottlerin is a polyphenol natural product isolated from the tree Mallotusphilippensis. Rottlerin displays a complex spectrum of pharmacology. Rottlerin has been shown to be an uncoupler of mitochondrial oxidative phospho...