150-Cavity Synchronization by Extended Loop in Neuraminidase of 2009 H1N1 Influenza Type A Virus: A Simulation Study
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 5
Abstract
Neuraminidase (NA) is a novel drug target for antiviral inhibitors. In this druggable target, a cavity adjacent to the active site exists and is known as the 150-cavity. NA is divided into two groups: Group 1 and Group 2. The 150-cavity is present in Group 1 and absent in Group 2. Its behaviour is largely dependent on the nature of the 150-loop. H1N1 pandemic virus is believed to be an exception to this norm because it lies in Group 1 but doesn’t contain the 150-cavity. Recent studies have shown that H1N1, also known as 2009N1, is capable of showing transition states that are characterized by different conformations of 150-loop. This 100-ns simulation study and subsequent analysis focused on identifying different conformations and develop an insight into the 150-loop which is directly responsible for transition states as well as 150-cavity formation. The study indicates direct regulating participation and involvement of a modifed, extended 150-loop (144-156) in the formation of 150-cavity.
Authors and Affiliations
Sudha Singh| Department of Biological Science and Engineering, Maulana Azad National Institute of Technology, Bhopal, Madhya Pradesh, India, Anvita Gupta Malhotra| Department of Biological Science and Engineering, Maulana Azad National Institute of Technology, Bhopal, Madhya Pradesh, India, Mohit Jha| Department of Biological Science and Engineering, Maulana Azad National Institute of Technology, Bhopal, Madhya Pradesh, India, Khushhali M Pandey| Department of Biological Science and Engineering, Maulana Azad National Institute of Technology, Bhopal, Madhya Pradesh, India, Corresponding e-mail: kmpbiomanit@gmail.com; khushhalimenaria@manit.ac.in
Keywords
Related Articles
- EP ID EP12366
- DOI -
- Views 325
- Downloads 14
Post Blood Transfusion Hypertensive Encephalopathy in a Child with Congenital Hemolytic Anemia: A Case Report
Introduction: Children having hemolytic anemias who have received multiple blood transfusions exhibit a rare complication of development of hypertension and seizures following transfusion, which may or may not be associ...
To compare the effect of Active Neural Mobilization during Intermittent Lumbar Traction and Intermittent Lumbar Traction followed by Active Neural Mobilization in cases of Lumbar Radiculopathy
To compare the effectiveness of Active neural mobilization (ANM) during intermittent lumbar traction (ILT) and intermittent lumbar traction followed by active neural mobilization treatment in patients of low back pain (...
Evaluation of the Effect of Educating Self Care Behavior of Heart failure Patients on Economy of Health
Heart disease is the most costly reason for hospitalization. The purpose of this research was evaluation of the influence of teaching self care behavior for heart failure patients on economy of health in hospitals in t...
MORPHOMETRY OF THE ARTICULAR FACETS ON THE SUPERIOR, MEDIAL AND LATERAL SURFACES OF THE BODY OF TALUS AND ITS CLINICAL RELEVANCE
Background: In the formation of Ankle joint, tibio-fibular mortice receives superior, medial and lateral articular surfaces of body of Talus. Because of very limited availability of the data on the Morphometry of the ar...
RARE PRESENTATION OF PITUITARY ADENOMA WITH OPHTHALMOPLEGIA
Pituitary Adenomas are benign intracellular tumours accounting for 10% to 15% of all intracranial neoplasms. They usually affect the adult population between the fourth and sixth decades of life. The prevalence of Pitui...