1H-NMR based serum metabolomic signatures imperative in retinalneurodegeneration and development of Diabetic Retinopathy
Journal Title: International Journal of Medical Research and Review - Year 2016, Vol 4, Issue 6
Abstract
Aim: To identify serum metabolomic fingerprints using 1H-NMR in Diabetic Retinopathy (DR). Methods and Materials: 1H-NMR was performed on 32 subjects [11 type 2 diabetic patients each without DR (group A) and with DR (group B) along with 10 control (group C)]. Results: The study unraveled 1H-NMR based serum metabolomic fingerprints of diabetic retinopathy showed significant variations in Ribitol, D-glucose, Fructose-6-phosphate, Uridine Diphosphate-N-acetyl glucosamine and Glycerophosphocholine. The study envisaged that abnormal polyol metabolism and accumulation of ribitol contributory to development of diabetic retinopathy. Presence of Uridine Diphosphate-Nacetylglucosamine in blood has been also confirmed its probable role in progressive neurodegeneration in diabetic retinopathy. NMR spectra also indicated that downregulation of glycerophosphocholine is directly related to retinol metabolism and subsequent unusual chromophore synthesis facilitating retinal degeneration. Conclusion: Five metabolomic fingerprints have been identified and found to be unique in Diabetic Retinopathy (DR).
Authors and Affiliations
Arpan Guha Mazumder, Sambuddha Ghosh, Swarnendu Bag, Sumanta Bera,, Srutarshi Ghosh, Anirban Mukherjee, Jyotirmoy Chatterjee
Keywords
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- EP ID EP230292
- DOI 10.17511
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