2-Methyl-4,6-dinitrophenol. Determination in workplace air
Journal Title: Podstawy i Metody Oceny Środowiska Pracy - Year 2016, Vol 32, Issue 1
Abstract
2-Methyl-4,6-dinitrophenol (DNOC) is a yellow crystalline solid. It has insecticidal, fungicidal and herbicidal properties. Nowadays, DNOC is used as a polymerization inhibitor and as an intermediate in the chemical industry. It is extremely toxic to humans.The aim of this study was to develop a new method for determining DNOC concentrations in workplace air in the range from 1/10 to 2 MAC values in accordance with the requirements of Standard No. EN 482.The study was performed using a liquid chromatograph (Agilent Technologies series 1200) with a diode array detector (DAD). Thedetermination was performed in the reversephase system (mobile phase: methanol: solution of acetic acid) using an Ultra C18 column (250 × 4.6 mm with dp = 5 μm).The method was based on passing air through a silica gel tube. Samples were desorbed with methanol and analyzed with HPLC-DAD. The procedure was validated according to StandardNo. EN 482. The measuring range was 0.005 ÷0,1 mg/m[sup]3[/sup], the limit of detection (LOD) was 1.55 ng/ml, the limit of quantifi cation (LOQ) was 4.66 ng/ml, the overall accuracy of the method was 5.24% and the relative total uncertainty of themethod was 11.5%.The analytical method described in this paper makes it possible to selectively determine DNOC in workplace air in the presence of phenols and cresols at concentrations from 0.005 mg/m³ (1/10MAC value). The method is precise, accurate and it meets the criteria for proce-dures for measuring chemical agents listed in Standard No. EN 482.The developed method of determining DNOC has been recorded as an analytical procedure (see appendix).
Authors and Affiliations
Anna Jeżewska
Keywords
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