A study of alcohol use and abuse among patients with multidrug-resistant tuberculosis reported at urban health centre of tertiary care teaching hospital in Mumbai
Journal Title: Medpulse International Journal of Community Medicine - Year 2017, Vol 3, Issue 1
Abstract
Background: The prevalence of multidrug resistant tuberculosis (MDR-TB) in India, in newly diagnosed cases is 2.1% and in previously treated cases is 13% to 17%. MDR-TB is much more fatal whenever associated with alcohol consumption. Consumption of alcohol worsens the course of MDR-TB due to changes in drug pharmacokinetics. Literature shows alcohol uses to be associated with higher rates of MDR-TB elsewhere in the world. Therefore this study was planned to study how alcohol use is associated with MDR-TB. Objectives: 1. To describe the pattern of alcohol use in MDR-TB patients and 2. To determine whether alcohol use is associated with the development of MDR-TB. Methods: A case control study was conducted in patients attending urban health training center during the period of June to November 2014. A total 76 cases with gene x-pert diagnosis of pulmonary MDR-TB and 76 control group I of patients with confirmed non-MDR pulmonary TB on gene x-pert and 76 control group II, participants from the general population without prior history of TB. To measure alcohol consumption, Alcohol use disorders identification test (AUDIT)-10 questionnaire was used. To find the significant association between different variables and cases, chi square test and Kruskal-Wallis tests were applied. Results: About 34.21% of MDR-TB cases reported alcohol consumption. MDR-TB cases had significantly higher mean scores of different domains of alcohol consumption as per WHO AUDIT-10 score. Alcohol abuse was found to be significantly associated with MDR tuberculosis. Conclusion: The finding of our study stress the fact that alcohol addiction among MDR-TB is unacceptably high that may worsen the cure rate of cases.
Authors and Affiliations
Raghuveer Chandel, Yogita Bavaskar, Mohan Doibale
Keywords
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