(3) A RANDOMIZED TRIAL COMPARING INTRAVENOUS IMMUNE GLOBLULIN AND PLASMA EXCHANGE IN GULLAIN – BARRE SYNDROME
Journal Title: Indian journal of applied basic medical sciences - Year 2014, Vol 16, Issue 22
Abstract
ABSTRACTS : BACKGROUND : The sub acute demyelinating polyneuropathy knows as Gullian–Barre syndrome improves more rapidly with plasma exchange. We conducted study of 50 patients to compare response of plasma exchange vs IVIG. METHODS : we have enrolled patients who had been diagnosed as gullian–barre dyndrome , which include clinical laboratory and electrophysiological diagnostic features. They were randomly assigned to receive either five plasma exchanges (50 ml/kg) on five separate sitting over 1-2 weeks or five doses of IVIg (0.4g /kg per day).The predefined outcome measure was improvement at four weeks by at least one grade of motor function. RESULTS : Median time to start recovery after plasma exchange was 6 days compare to 5 days of IVIG. 70 % of patients improve more than one grade at 4 weeks compare to 69.23% of IVIG. CONCLUSION : In the acute Gullian-Barre syndrome, treatment with IVIg is at least as effective as plasma exchange.
Authors and Affiliations
Cecil parmar, chirag patel
Keywords
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