6 COMPARISON OF EPIDURAL BUTORPHANOL VERSUS FENTANYL WITH BUPIVACAINE FOR POST OPERATIVE ANALGESIA IN LOWER ABDOMINAL AND LOWER LIMB SURGERIES
Journal Title: Indian journal of applied basic medical sciences - Year 2015, Vol 17, Issue 25
Abstract
Background: This prospective randomized controlled clinical comparative study entitled “COMPARISON OF EPIDURAL BUPIVACAINE AND BUTORPHANOL VERSUS EPIDURAL BUPIVACAINE AND FENTANYL FOR POST OPERATIVE ANALGESIA IN LOWER ABDOMINAL AND LOWER LIMB SURGERIES” was conducted in 50 patients of either sex, aged between 18- 60 years of ASA grade Ι and ΙΙ admitted for elective surgeries during 2011-2013. Material & Method: Written informed consent was taken and pre-anesthetic evaluation was done. Epidural catheter was inserted and all patients were given spinal anesthesia using 0.5% hyperbaric Bupivacaine (15mg). In the postoperative period, when patient complained of pain, intensity of pain was assessed using Visual analog scale and when VAS score was 4 or more they received epidural Bupivacaine (0.5%) 2.5 ml and Butorphanol 2mg (group BB) or Bupivacaine (0.5%) 2.5 ml and Fentanyl 50µg (group BF) diluted to 10ml with NS. Parameters were observed were; Onset of analgesia; Duration of analgesia. ; Cardio- respiratory effects and adverse effects. Demographic profile (age, sex weight hemodynamics and ASA grade) was comparable in both groups. Onset of analgesia: Mean onset of analgesia was rapid (4.5+1.06S.D) minutes) in group BF when compared to group BB (6+1.32 (S.D) minutes. This was clinically and statistically significant (p< 0.001). Duration of analgesia: Duration of analgesia was longer in group BB which ranged from 300-550 minutes with a mean of 410+50.29 minutes compared to group BF which ranged from 250-450 minutes with a mean of 330+39.32 minutes. This was clinically and statistically significant (p< 0.001). Cardio- respiratory effects: There was no significant difference in heart rate, blood pressure and respiratory rate monitored at regular intervals for 12 hours postoperatively between the two study groups. Adverse effects: Sedation was the main side effect in group BB. Frequency of pruritis and nausea-vomiting was more in group BF. Hypotension and respiratory depression were not found statistically significant in either group. All patients were monitored for 12 hours postoperatively for any untoward effects.
Authors and Affiliations
Dr. Rupal J Shah, Dr. Manisha S Kapdi
Keywords
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