-643C/T polymorphism of RANKL gene and its association with osteoporosis in postmenopausal women

Apply

-643C/T polymorphism of RANKL gene and its association with osteoporosis in postmenopausal women

Journal Title: Annales Academiae Medicae Silesiensis - Year 2014, Vol 68, Issue 6

Abstract

INTRODUCTION RANKL is a key cytokine involved in osteoclast differentiation from its precursors, activation and survival of osteoclasts themselves. Because RANKL binds with RANK, the presence of RANK on target cells is a neces-sary condition of target cell control mediated by RANKL. AIM OF STUDY The aim of the study was to examine the incidence of RANKL gene polymorphism and evaluate its association with the clinical parameters concerning bone turnover and the degree of postmenopausal osteoporosis development. MATERIAL AND METHODS The study was conducted among a group of 570 women at postmenopausal age (404) and reproductive age (166). The group at postmenopausal age included women with osteoporosis, osteopenia as well as healthy individuals. The women at reproductive age were healthy. The polymorphism incidence of the examined gene in a group of patients with determined bone mineral density (BMD) and in the control group was studied. The study was performed by means of the RFLP-PCR method. RESULTS The obtained results did not show a correlation of RANKL gene C-643T polymorphism with decreased bone density or increased risk of osteoporotic changes after menopause. CONCLUSIONS The homozygote of the TT polymorphism of the RANKL receptor gene seems to be an increased risk factor of osteoporosis development and is associated with growth and birth mass.

Authors and Affiliations

Dariusz Boroń, Ariel Plewka, Przemysław Jędrusik

Keywords

EP ID EP376452
DOI -
Views 79
Downloads 0