7 Comparative Study of Drotaverine Hydrochloride and Valethamate Bromide in rate of cervical dilatation
Journal Title: Indian journal of applied basic medical sciences - Year 2017, Vol 19, Issue 29
Abstract
OBJECTIVE: To evaluate and compare the effects of drotaverine and valethamate on cervical dilatation. METHODS: This was a prospective study conducted in a tertiary center over a span of 6 months. 90 patients were randomly allotted in 3 groups. 1. 30 patients (15 primigravida and 15 multigravida)- control group 2. 30 patients (15 primigravida and 15 multigravida) – Injection Drotaverine 3. 30 patients (15 primigravida and 15 multigravida) – Injection Valethamate The drotaverine (D) and valethamate (V) groups were given intravenously 40 mg drotaverine hydrochloride to group D with every 2 hours for a maximum of 3 doses 8 mg valethamate bromide to group V with maximum of 3 doses one hour apart. The control group given 2ml inj. normal saline intravenously as placebo. RESULTS: In primigravidae and multigravidae the average duration of active phase is shortened by 3 hours with 2.9+1cm/ hour cervical dilatation in drotaverine group and 1 hour 45 minutes with 1.9+1.1cm/hour in valethamate group (p-value <0.05). There was no significant difference in the duration of second and third stages in both groups. No obstetrical complications or major side effects observed in both groups. CONCLUSION: Drotaverine accelerates labor better than of valethamae. The reduction of pain during labor is better with drotaverine when compared with valethamate.
Authors and Affiliations
Dr. Shuchi Patel, Dr. Samipa Shah
Keywords
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