A 16-year-old female presenting with Splenic Marginal Zone Lymphoma indistinguishable from Hyperactive Malaria Splenomegaly syndrome.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 8
Abstract
Introduction: Splenomegaly is frequently observed among children and adolescents who reside in malaria endemic areas. Clinically, these are frequently complicated by hypersplenism, therefore defined as Hyperactive Malaria Splenomegaly (HMS. The underlying pathology of HMS is unknown, but is indistinguishable from splenic lymphomas such as splenic marginal zone lymphomas (SMZL). We present a case of SMZL in a Kenyan adolescent whose disease meets the clinical criteria of HMS. Case Report: We present a case of a 16-year-old female who was referred to a tertiary teaching hospital in Kenya with massive splenomegaly, anaemia and peripheral blood lymphocytosis. Bone marrow studies showed infiltrative sinusoidal neoplastic atypical B lymphocytes. The eventual diagnosis on histology and clinicalpathological correlation is a Splenic marginal zone lymphoma. The patient received combination chemotherapy, antimalarial therapy with resolution of symptoms and splenomegaly. Conclusion: This case suggests that SMZL could be the underlying lesion in HMS. Evaluation of SMZL should be performed in all suspected cases of HMS. Clinical – Pathological series should be performed to identify the underlying pathology of HMS.
Authors and Affiliations
Oyiro Peter, Edwin Walong
Keywords
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- EP ID EP381472
- DOI 10.9790/0853-1708116971.
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