A BRIEF REVIEW ON WEGENER’S GRANULOMATOSIS AND ITS TREATMENT

Journal Title: Indo American Journal of Pharmaceutical Sciences - Year 2018, Vol 5, Issue 2

Abstract

Wegener's Granulomatosis (WG) which is otherwise called as Granulomatosis with polyangiitis (GPA) is an uncommon multi system autoimmune diseases, which is exceptionally connected with Anti-Neutrophil Cytoplasmic Antibodies (ANCA). Wegner's Granulomatosis is a complex multisystem vasculitic disease characterized by necrotizing small arteries and veins of unknown reason. In WG remission can be accomplished by regular immunosuppressive treatment. The causes of WG includes infectious and environmental triggers, drug induced ANCA-associated vasculitis (AAV) and also genetic factors. Staphylococcus aureus is a common micro-organism implicated in the pathogenesis of WG and the repeating, relapsing nature of the disease might be connected to steady colonization of nasal sections with this organism. Staphylococcus aureus creates super antigens which activate B and T Cells, and through a procedure of sub-atomic mimicry Staphylococcus aureus can likewise actuate AAV. The symptoms of WG include fevers, conjunctivitis, rhinitis, cough, myalgia, and necrosis. The diagnostic tests include ANCA testing, chest radiography, CT scanning, abnormal kidney function tests etc. Wegener’s granulomatosis affects various organs such as heart, eye, kidneys and lungs. Treatment of WG is considered to have two stages: induction, where active infection is put into remission; and support, where remission is managed. The backbone of treatment for WG is a mix of corticosteroids and cytotoxic agents. Keywords: Wegener’s granulomatosis, vasculitis, Anti-Neutrophil Cytoplasmic Antibodies, cyclophosphamide.

Authors and Affiliations

Keywords

Wegener's Granulomatosis (WG) which is otherwise called as Granulomatosis with polyangiitis (GPA) is an uncommon multi system autoimmune diseases which is exceptionally connected with Anti-Neutrophil Cytoplasmic Antibodies (ANCA). Wegner's Granulomatosis is a complex multisystem vasculitic disease characterized by necrotizing small arteries and veins of unknown reason. In WG remission can be accomplished by regular immunosuppressive treatment. The causes of WG includes infectious and environmental triggers drug induced ANCA-associated vasculitis (AAV) and also genetic factors. Staphylococcus aureus is a common micro-organism implicated in the pathogenesis of WG and the repeating relapsing nature of the disease might be connected to steady colonization of nasal sections with this organism. Staphylococcus aureus creates super antigens which activate B and T Cells and through a procedure of sub-atomic mimicry Staphylococcus aureus can likewise actuate AAV. The symptoms of WG include fevers conjunctivitis rhinitis cough myalgia and necrosis. The diagnostic tests include ANCA testing chest radiography CT scanning abnormal kidney function tests etc. Wegener’s granulomatosis affects various organs such as heart eye kidneys and lungs. Treatment of WG is considered to have two stages: induction where active infection is put into remission; and support where remission is managed. The backbone of treatment for WG is a mix of corticosteroids and cytotoxic agents. Keywords: Wegener’s granulomatosis vasculitis Anti-Neutrophil Cytoplasmic Antibodies cyclophosphamide.

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  • EP ID EP267736
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How To Cite

(2018). A BRIEF REVIEW ON WEGENER’S GRANULOMATOSIS AND ITS TREATMENT. Indo American Journal of Pharmaceutical Sciences, 5(2), 1237-1245. https://europub.co.uk/articles/-A-267736