A Case of Multiple Myeloma Presenting with Diabetes Insipidus
Journal Title: Sultan Qaboos University Medical Journal - Year 2017, Vol 17, Issue 2
Abstract
Multiple myeloma (MM) can present with involvement of the central nervous system in the form of nerve palsy, plasma cell masses or, rarely, with endocrinological effects due to involvement of the pituitary gland. Usually, in such cases, the disease has a rapid progression and poor prognosis. We report a 52-year-old man who was admitted to the Kolkata Medical College, Kolkata, India, in 2016 with a prolonged low-grade fever and hypernatremia. Shortly afterwards, the patient began to complain of increased urinary frequency and drowsiness. Te hypernatremia was treated with intranasal desmopressin and free water replacement. Serum protein electrophoresis and an immunofxation study revealed an immunoglobulin G-κ monoclonal band. Magnetic resonance imaging of the pituitary gland revealed the absence of a posterior bright spot and spotty infltration of the pituitary fossa. A bone marrow biopsy confrmed a diagnosis of cranial diabetes insipidus due to posterior pituitary MM infltration.
Authors and Affiliations
Rudrajit Paul| Department of Medicine, Kolkata Medical College, Kolkata, West Bengal, India, Aditya V. Ruia| Department of Medicine, Kolkata Medical College, Kolkata, West Bengal, India, Asim Saha| Department of Medicine, Kolkata Medical College, Kolkata, West Bengal, India, Jayati Mondal| Department of Gynaecology, Chittaranjan Seva Sadan Hospital, Kolkata, West Bengal, India, T. J. Sau| Department of Medicine, Kolkata Medical College, Kolkata, West Bengal, India, Indranil Takur| Department of Medicine, Kolkata Medical College, Kolkata, West Bengal, India, Kunal Haldar| Department of Medicine, Kolkata Medical College, Kolkata, West Bengal, India
Keywords
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- EP ID EP14777
- DOI 10.18295/squmj.2016.17.02.015
- Views 290
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