A Case of Reversible Posterior Leukoencephalopathy Syndrome (RPLS) in Granulomatosis with Polyangitis (GPA)
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 1
Abstract
A 14 years old boy from Saudi Arabia arrived to emergency room with diffuse abdominal pain, nausea and frequent non bloody, non-bilious vomiting. On examination, he had pale conjunctiva, some erythematous purpuric rash which appeared over his cheeks and both arms, not painful or itchy with mild epigastric tenderness, no signs of volume overload. Urine dipstick showed ++++ blood and + protein. High-resolution computed tomography (HRCT) showed small peripheral infiltrations at the base of the right lung and bilateral pleural effusion. Based on clinical, histopathological (kidney and skin biopsies) along with high C ANCA titer the patient diagnosed as having GPA. After we started him on treatment he developed status epilepticus and MRI brain showed classical findings of RPLS, which later resolved completely. Final diagnosis was reversible posterior leukoencephalopathy syndrome (RPLS) in GPA. In conclusion, RPLS is an important, rare entity to be recognized in patients with GPA and other connective tissue diseases. It is important to differentiate RPLS from other common CNS disorders found in patients with autoimmune diseases.
Authors and Affiliations
Hana Alahmari, Mansour Somaily
Keywords
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- EP ID EP542603
- DOI 10.21276/ijmrp.2017.3.1.041
- Views 78
- Downloads 0
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