A Case of Sarcoidosis Presenting as Cirrhosis and Portal Hypertension
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 25
Abstract
Sarcoidosis is a systemic granulomatous disease of unknown etiology that can involve nearly all organs. Liver is the third most commonly affected organ following the lungs and the lymph nodes. Cases with liver sarcoidosis are usually silent clinically while a few can progress to cirrhosis and portal hypertension in less than 1% of the patients. A 56 year old female was referred for ecchymosis, protuberant abdomen, bilateral pretibial and ankle edema. Medical history did not reveal any previous disease. Ascites, hepatomegaly, splenomegaly, and facial telengiectasies were present on physical examination. Chest x-ray and CT were normal. Papules and plaques on the knees developed six days after admission. Skin biopsy revealed granulomatous dermatitis. Serum ACE was 250 IU/L. Liver biopsy showed non-caseiting granulomas, severe hepatitis and fibrosis. Sarcoidosis was confirmed based on high serum ACE, histopathologic findings of the skin and liver biopsy samples that revealed non-caseiting granulomas. We report a case of sarcoidosis complicated by cirrhosis as the initial manifestation of the disease without lung involvement. An extensive literature review of sarcoidosis, focusing on case reports, which presented with cirrhosis and portal hypertension without lung involvement, was made.
Authors and Affiliations
Halil Yanardag, Cuneyt Tetikkurt, Aslı Sezgin, Nuray Kepil, Muammer Bilir
Keywords
Related Articles
- EP ID EP349076
- DOI 10.9734/BJMMR/2014/9568
- Views 66
- Downloads 0
Effect of Symptom Graduation on Oncologic Outcomes in Patients with Renal Cell Carcinoma and Hematuria
Aims: Symptoms associated with renal cell carcinoma characterize high-risk disease. Hematuria is the most common symptom and usually occurs as a result of urothelial invasion. The objective of this study was to evaluate...
Evidence of Overlapping Infections of Dengue, Malaria and Typhoid in Febrile Patients Attending a Tertiary Health Facility in Uyo, South-South Nigeria
Background: Malaria, typhoid, and dengue have become significant diseases worldwide, especially in Africa due to their increasing endemicity. Similarities in signs and symptoms in infected individuals make it difficult f...
Potential Risk of Respiratory Secretions in the Transmission of HBV Infection: A Review of the Literature
Hepatitis B virus (HBV) infection is a significant health problem around the world and may cause serious morbidity and mortality. The most common transmission routes are parenteral, sexual, perinatal and horizontal way....
Factors Associated with a Low CD4 Count among HIV-1 Infected Patients at Enrolment into HAART in Jos, Nigeria
Aim: To determine the factors associated with a low CD4 count among HIV-1 positive patients. Study Design: Cross-sectional study. Place and Duration of Study: Adult HIV clinic at the Jos University Teaching Hospital, Jos...
The Effect Birth Interval on Fetal Outcome at the University of Maiduguri Teaching Hospital – A Cross Sectional Study
Background: Birth spacing is a well-known and underutilized health intervention. Longer birth intervals are associated with multiple health benefits for both mother and the child. Aim: To determine the effect of birth in...