A CASE REPORT OF CARDIOTOXICITY DUE TO HOMEOPATHIC DRUG OVERDOSE
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2014, Vol 3, Issue 4
Abstract
Aconite is one of the most toxic plants. Aconitine and related alkaloids found in the Aconitum species are highly toxic cardiotoxins and neurotoxins. Severe aconite poisoning can occur after accidental ingestion of the wild plant or consumption of an herbal decoction made from aconite roots. The toxic components of Aconitum as aconitine and related alkaloids cause cardiotoxicity, neurotoxicity and gastrointestinal toxicity through their actions on sodium channels. Cardiac manifestations include hypotension and ventricular tachyarrhythmias. Ventricular tachyarrhythmias and refractory cardiovascular collapse, such as in the case of this patient account for lifethreatening toxicities in severe aconite poisoning. In general, vagal slowing is seen in 10 to 20% of fatal intoxications. If higher concentrations are present, supraventricular tachycardia, ventricular tachycardia, torsades de pointes, and other conduction disturbances may be seen. Ventricular fibrillation may be seen, and is often the cause of death. Available clinical evidence suggests that drugs like amiodarone and flecainide are reasonable firstline treatment.
Authors and Affiliations
MilindChandurkar| Professor and Head, Department of Medicine, Rural Medical College of PIMS (DU), Loni, Ahmednagar, Maharashtra, Corresponding author email: drmilindch@gmail.com, Girish Patrike| PG Resident, Department of Medicine, Rural Medical College of PIMS (DU), Loni, Ahmednagar, Maharashtra, NitinChauhan| PG Resident, Department of Medicine, Rural Medical College of PIMS (DU), Loni, Ahmednagar, Maharashtra, SanketMulay| PG Resident, Department of Medicine, Rural Medical College of PIMS (DU), Loni, Ahmednagar, Maharashtra, Manoj Vethekar| PG Resident, Department of Medicine, Rural Medical College of PIMS (DU), Loni, Ahmednagar, Maharashtra, JaweedAkhtar| PG Resident, Department of Medicine, Rural Medical College of PIMS (DU), Loni, Ahmednagar, Maharashtra, Mallikarjun Reddy| PG Resident, Department of Medicine, Rural Medical College of PIMS (DU), Loni, Ahmednagar, Maharashtra
Keywords
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- DOI 10.5958/2319-5886.2014.00057.5
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