A Case Report of Fosphenytoin Induced Orofacial Dyskinesia in an 11-month-old Baby with Post-encephalitic Sequelae
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 5
Abstract
ABSTRACT Fosphenytoin is used as an alternative phosphate ester prodrug to intravenous phenytoin for seizure treatment. Acute orofacial dyskinesia, secondary to phenytoin treatment is very uncommon. This case report gives the details of an 11-month-old baby girl, with post encephalitic sequelae, who developed orofacial dyskinesia during treatment with fosphenytoin. She was on fosphenytoin for the last 11 days. She presented with lip smacking movements on the 11th day of administration of fosphenytoin. At the time of presentation of orofacial dyskinesia, she found it difficult to keep her tongue inside her mouth and the involuntary movements subsided following the withdrawal of the drug. In this case, it was a probable cause of the relationship between the patient’s symptoms and the use of fosphenytoin according to the causality assessment scales such as the Naranjo scale and the World Health Organisation (WHO) Uppsala Monitoring Centre causality assessment system. She had a score of six. Also, the reaction is not likely to be owing to coexisting diseases or drugs. Though fosphenytoin induced orofacial dyskinesia is infrequent, there is a need to consider the adverse effects of fosphenytoin as a differential diagnosis in all patients with a movement disorder in the course of fosphenytoin treatment.
Authors and Affiliations
George Mathew Panachiyil, Tirin Babu, Juny Sebastian, Mandyam Dhati Ravi
Keywords
Related Articles
- EP ID EP583358
- DOI 10.7860/JCDR/2019/41483.12869
- Views 99
- Downloads 0
Correlation of Plasma Neutrophil Elastase Activity and Endogenous Protease Inhibitor Levels with the Severity of Pre-eclampsia
Introduction: Pre-eclampsia (PE) is a common maternal syndrome characterized by severe systemic inflammatory response including neutrophil activation leading to uncontrolled activity of elastase. The excessive activity o...
Sudden Death in a Child: The Mystery Behind the Cardiac Mass
ABSTRACT A 12-year-old boy suddenly collapsed while playing and was brought to the emergency department, where he was declared dead. The child had no prior medical illness. On autopsy examination, a dumbbell shaped mass...
Prinzmetals Angina Masquerading as Acute Pericarditis
Coronary artery spasm is an intense vasoconstriction of the coronary arteries and may be responsible for the myocardial ischemia, myocardial infarction as well as sudden deaths. Coronary angiography is generally needed t...
Clinico-radiological Difference between Primary and Secondary MDR Pulmonary Tuberculosis
ABSTRACT Introduction: Multidrug Resistant Tuberculosis (MDR-TB) is classified into primary and secondary type depending upon history of Anti-TB drug received in past. MDR-TB generally remains undetected in newly detecte...
Impact of a Publication Ethics Orientation Program on the Knowledge and Attitude of Postgraduate Students of Health Sciences
ABSTRACT Introduction: Pressure to publish and for better academic recognition, issues of publication misconduct like plagiarism, data fabrication and falsification, authorship disputes, conflict of interest, redundant a...