A CLINICAL, HISTOPATHOLOGICAL AND DIRECT IMMUNOFLUORESCENCE CORRELATION OF AUTOIMMUNE BULLOUS DISORDERS
Journal Title: IJSR-International Journal Of Scientific Research - Year 2017, Vol 6, Issue 10
Abstract
Background: Autoimmune vesiculobullous disorders are group of blistering dermatoses in which pathogenic autoantibodies are present against various antigens against adhesion molecules in epidermis and dermo-epidermal junction which leads to blister formation. Aims: To study various clinical patterns and morphology of autoimmune bullous disorders and their histopathological findings along with direct immunofluorescence findings and to correlate between clinical, histopathological and immunofluorescence findings. Materials and Methods: A cross sectional study was done on 70 patients in OPD of dermatology department, detailed clinical history, examinations and routine investigations were done and recorded. Two biopsies from lesion and perilesional skin were done for histopathology and immunofluorescence respectively. Results: The clinical, histopathological and direct immunofluorescence concordance for cases ranged from 0% to 100%.The concordance was 81.39% in pemphigus vulgaris, 72.73% in pemphigus foliaceus, 62.5% in bullous pemphigoid and, 40% in dermatitis herpetiformis. We had two cases of linear IgA bullous dermatitis and only one case of Pemphigoid gestationalis. The percentages of concordance in these cases were 100%, for both. Out of 70 cases of autoimmune vesiculobullous diseases clinical, histopathological and immunological correlation was present in 54 cases (77.14%).
Authors and Affiliations
Dr Dimple Chopra, Dr Santpal Sangwan, Dr Rakesh Bahl, Dr Navdeep Arora, Dr Aastha Sharma
Keywords
Related Articles
- EP ID EP512079
- DOI -
- Views 47
- Downloads 0
A Comparative Study of Association Between Birth Weight of Newborns and Anaemia in Mothers in an Urban Slum of Mumbai
Low Birth Weight (LBW) is one of the most serious challenges in maternal and child health in both developed and developing countries. Objective was to study the association between the birth weight of newborns and anaemi...
TO STUDY 25 (OH) D LEVELS IN PATIENTS WITH NON ALCOHOLIC FATTY LIVER DISEASE
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease and its increasing incidence has been well documented from Asian countries. Diabetes mellitus (DM), obesity, hyperlipidemia...
“THE RIGHT TO LIFE”: FEMALE INFANTICIDE AND FETICIDE: AN ANALYSIS OF INDIA
Female infanticide and female feticide (the selective abortion of girls in the womb) are significant issues in India. Female infanticide has been a problem for centuries, partly as a result of the patriarchal nature of I...
Study of Electrolyte Disturbances in Seizure Disorders
Introduction:- This study conducted on children having seizures whose serum electrolyte levels were analyzed. Material & Methods:- Reports of children from 0 to 12 years of age were subjected to mean, standard deviation,...
KNOWLEDGE, ATTITUDES, AND PRACTICES REGARDING THE INFLUENZA VACCINE AMONG ADULTS ATTENDING PRIMARY HEALTHCARE CLINICS IN DAMMAM, SAUDI ARABIA
The aim of this study was to measure the uptake of influenza vaccine and to assess knowledge, attitudes, and practices towards influenza vaccine among adults attending primary healthcare centres in Dammam, Saudi Arabia....