A CLINICAL, HISTOPATHOLOGICAL AND DIRECT IMMUNOFLUORESCENCE CORRELATION OF AUTOIMMUNE BULLOUS DISORDERS
Journal Title: IJSR-International Journal Of Scientific Research - Year 2017, Vol 6, Issue 10
Abstract
Background: Autoimmune vesiculobullous disorders are group of blistering dermatoses in which pathogenic autoantibodies are present against various antigens against adhesion molecules in epidermis and dermo-epidermal junction which leads to blister formation. Aims: To study various clinical patterns and morphology of autoimmune bullous disorders and their histopathological findings along with direct immunofluorescence findings and to correlate between clinical, histopathological and immunofluorescence findings. Materials and Methods: A cross sectional study was done on 70 patients in OPD of dermatology department, detailed clinical history, examinations and routine investigations were done and recorded. Two biopsies from lesion and perilesional skin were done for histopathology and immunofluorescence respectively. Results: The clinical, histopathological and direct immunofluorescence concordance for cases ranged from 0% to 100%.The concordance was 81.39% in pemphigus vulgaris, 72.73% in pemphigus foliaceus, 62.5% in bullous pemphigoid and, 40% in dermatitis herpetiformis. We had two cases of linear IgA bullous dermatitis and only one case of Pemphigoid gestationalis. The percentages of concordance in these cases were 100%, for both. Out of 70 cases of autoimmune vesiculobullous diseases clinical, histopathological and immunological correlation was present in 54 cases (77.14%).
Authors and Affiliations
Dr Dimple Chopra, Dr Santpal Sangwan, Dr Rakesh Bahl, Dr Navdeep Arora, Dr Aastha Sharma
Keywords
Related Articles
- EP ID EP512079
- DOI -
- Views 59
- Downloads 0
COMPARISON OF UMBILICAL CORD MILKING AND DELAYED CORD CLAMPING ON HAEMOGLOBIN AND HAEMATOCRIT LEVELS IN TERM NEONATES. A RANDOMIZED CONTROLLED TRIAL.
Background: Delayed umbilical cord clamping is an effective strategy and particularly relevant for infants living in low-resource settings with less access to iron-rich foods and thus are at greater risk of anaemia. Obje...
KNOWLEDGE AND ATTITUDE ABOUT BASIC LIFE SUPPORT AMONG SCHOOL TEACHERS IN EASTERN PROVINCE
introduction: Bystander Cardiopulmonary Resuscitation (CPR) is a vital life-saving intervention, easy skills to learn and performed when witnessing a victim of cardiopulmonary arrest. since the School teachers are the fi...
VARIATIONS IN BRANCHING PATTERN OF BRACHIAL ARTERY – A STUDY IN CADAVERS
Brachial artery in arm is commonly used for percutaneous arterial catheterization, angiography, vascular flaps for reconstructive surgeries, and can be injured in fractures of arm or elbow region. Knowledge of variations...
SCREENING FOR AMYLYOLYTIC AND BACTERIOCINOGENIC LACTIC ACID BACTERIA FROM CURD, MILK AND SOIL
In fermentation, bacteriocinogenic and amylolytic properties of lactic acid have been reported to be important functional properties. Lactic acid producing bacteria (Lactobacillus sp.) from milk and traditionally ferment...
COMPUTED TOMOGRAPHY SCAN AND THERAPEUTIC RESPONSE IN PATIENTS WITH NEUROCYSTICERCOSIS.
Neurocysticercosis (NCC) is the most common parasitic disease of the nervous system with varied clinical and imaging spectrum. This study was conducted to describe the clinical , CT finding and response to therapy of NCC...