A clinical study of 50 cases of nephritic syndrome with special reference to serum lipid profile and altered renal functions
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 12
Abstract
Nephrotic syndrome is a clinical complex characterized by a number of renal and extrarenal features, the most prominent of which are proteinuria, hypoalbuminuria edema and hyperlipidemia. It was recognised that primary glomerular lesions were responsible for majority of the cases of nephritic syndrome. Also results from a number of systemic diseases secondarily involving the kidneys can occur at any age starting from neonatal period (congenital nephrotic syndrome) to 8th or 9th decade. Aim of the study is to evaluate nephrotic syndrome patients clinically and biochemically in order to have a better understanding of the disease. Renal function is mildly decreased in nephrotic syndrome. Hyperlipidemia is a significant adverse component of nephrotic syndrome. Other consequences of nephrotic hyperlipidemia are increased platelet aggregation, increased susceptibility to infection and hyperlipidemia is a risk factor for progression of glomerular injury. Fifty cases of Nephrotic syndrome admitted to K.R. Hospital, Mysore, were studied priority given to changes in various lipid fractions and renal functions. Altered renal functions are seen in membranous, MPGN, FSGS and in case of SLE. Serum cholesterol was raised in FSGS, MPGN, membranous, and MCNS group. LDL and TG levels were raised in a few cases. HDL levels were within normal range except one case where it was high.
Authors and Affiliations
A Manjula
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