A clinical study of neurological manifestations in HIV positive patients in a tertiary care hospital of Telangana, India
Journal Title: International Archives of Integrated Medicine - Year 2018, Vol 5, Issue 1
Abstract
Background: Human Immunodeficiency Virus (HIV) infection is a global pandemic, India has second largest burden of HIV illness. Nervous system is most frequent and serious target of HIV infection. Aim: The main aim of our study was to evaluate the occurrence of various neurological manifestations in HIV positive patients and to correlate them with CD4 count at the time of presentation. Materials and methods: This prospective study was carried out for a period of 2 years from January 2014 to December 2016 in the Department of Neurology, Gandhi Hospital, Hyderabad, India. Those patients, who satisfied the inclusion criteria (>18 year of age; HIV positive; any gender) were included in our study. Patients who were HIV positive but having non neurological medical conditions were excluded. Those with various neurological symptoms were subjected to thorough neurological examination, whenever indicated neuroimaging, CSF analysis, NCS, Toxoplasma serology were done. CD4 count was done in all patients. Results: Our study enrolled a total of 1011 HIV positive patients, out of them 354(35%) patients had neurological manifestations. Among them, 239 (67.51%) were male and115 (32.48%) were female. We analyzed patients presented with various neurological symptoms, 187(52%) patients presented with parasthesias. CD4 count was done to all patients. Out of 354 patients, 188 (39.4%) patients had low CD4 count (<200μL). NCS was abnormal in 182 (51.4%) patients. Axonal sensory neuropathy was the most common abnormality found in 82 (45.0%) patients. The most common neurological manifestation was peripheral neuropathy, seen in 166 (46.8%) patients. Conclusion: HIV infection can affect all levels of the neuronal axis. Neurological manifestations are common in 4th decade of life and males affect more than females. Peripheral neuropathy was the most common neurological manifestation and Tuberculosis was the prominent infectious etiology. Neurological manifestations are seen with low CD4 count and there is a significant correlation between them hence can be stated that, these are the manifestations of the late stage of the disease.
Authors and Affiliations
Kamera Sateesh Kumar, Veena Narisetty, P. Chandra Shekar, Changala Praveen, Alluri Neeraja
Keywords
Related Articles
- EP ID EP413504
- DOI -
- Views 129
- Downloads 0
A comparative study of medical termination of pregnancy between 8-12 weeks with misoprostol versus mifepristone along with misoprostol at tertiary care hospital
Introduction: Medical method of abortion has advantages over surgical methods as it is non-invasive. Hence, no complications of anesthesia and administration of drugs is easy in medical methods. There is a need for evolv...
Comparing microleakage in Silorane based composite and nanofilled composite using different layering techniques in class I restorations: An in vitro study
Background: It won’t be wrong to admit that composite resins are currently the back bone of aesthetic and conservative dentistry. However a major drawback of composite resins is that their setting reaction involves forma...
Evaluation of serum calcium level in total thyroidectomy patients
Background: Thyroidectomy remains to be one of the most common surgeries done and has been associated with few specific complications. One major complication of thyroidectomy is hypocalcemia, which often occurs as a resu...
Comparison of Truviewscope and C-Mac Video Laryngoscope with the Conventional Macintosh Laryngoscope in Improving the Glottic View during Endotracheal Intubation
Background: In anesthetic practice, the introduction of multiple novel laryngoscopes has simplified visualization of the vocal cords and has reduced the complications arising due to difficult or failed tracheal intubatio...
A study of triple negative breast carcinomas
Aim and objectives: To show the incidence of triple negative breast carcinomas in the younger age group (20-40 years) in the study sample and to establish a correlation between expression patterns of estrogen receptor (E...