A Clinical Study of Sickle Cell Disease and its management with S-Compound
Journal Title: International Journal of Ayurveda and Pharmaceutical Chemistry - Year 2018, Vol 0, Issue 0
Abstract
The Sickle gene is widespread among many tribal population groups in India with prevalence varying from 1-40%. It is an inherited blood disorder most common among people of African, Arabian and Indian origin. The sickle cell mutation affects the B chain of adult hemoglobin which changes the behavior of sickle cell hemoglobin. The first case was described in the Nilgiri hills of the northern Tamilnadu in India in 1952. The common complications as documented is avascular necrosis of bones in the current study AVN seen in femoral head. Out of 120 total screened patients of SCD, 60 patients were randomly selected as per the inclusion and exclusion criteria with 15 patients in each group abiding the above criteria and categorized into total of four groups according to the atypical symptoms and complications along with primary disease that is SCD. Out of total 15 patients in each group, 10 patients were given the prepared S-Compound and the remaining 5 were given placebo. The results were analyzed within the groups before and after the treatment by paired âtâ test and the inter group analysis was carried out by unpaired âtâ test. Evaluation of the efficacy of trial drug comparing the all groups was carried out after the completion of the study. The percentage wise analysis showed increase in appetite in 54.38% patients, 49.54% of patients showed relief in repeated infections, 49.40% of patients showed decreased fever, 45.57% of patients exhibit reduced abdominal colic, palpitation was reduced in 45.29% of patients, 44.35% of patients showed decrease in body ache (pain and crisis), 43.75% of patient showed improvement in jaundice. The trial study was an initiative in ayurvedic field for designing a standard management regimen suitable for SCD patients or SCD patients with complications.
Authors and Affiliations
Chandreshwar Prasad Sinha, P K Baghel
Keywords
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