A CLINICAL STUDY ON ACUTE OPHTHALMIC MANIFESTATION AND MANAGEMENT OF STEVENSJOHNSON SYNDROME CONDUCTED AT A TERTIARY CENTRE OF THIRUVANANTHAPURAM, KERALA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 19
Abstract
BACKGROUND SJS (Stevens-Johnson Syndrome) is an acute life-threatening immune complex mediated hypersensitivity reaction to drugs that results in extensive necrosis and detachment of the epidermis, which shows widespread lesions affecting mouth, eyes, pharynx, larynx, skin, genitals etc. Acute ocular manifestation caused by SJS causes severe ocular morbidities if not treated at an early stage. MATERIALS AND METHODS A descriptive follow-up study was undertaken at Regional Institute of Ophthalmology (RIO), Thiruvananthapuram, Southern Kerala. Patients presented at Dermatology and General Medicine Department of Medical College Hospital, Thiruvananthapuram, identified with SJS were examined and called for detailed ocular evaluation at RIO. A total of 52 cases were screened during August 2009 to 2011 and all patients were told about the severity of disease and their detailed drug history, personal history and ocular symptoms were collected. Protocol based treatments were offered to all subjects and effect of treatment was studied during follow-up periods. Data of the patients was recorded on a prefabricated proforma. Data was statistically analysed to find out association and comparison between different parameters using non-parametric Chi-square (χ2) test. RESULTS 23.1% of SJS subjects showed toxicity to ciprofloxacin; 96.2% showed acute ophthalmic manifestation. Catarrhal type of conjunctivitis was the commonest, which responds well to terramycin eye ointment and frequent irrigation of eyes. Corneal erosions and corneal ulceration in the acute period were reduced in the follow-up period due to active ophthalmic intervention in the early period. CONCLUSION 1. SJS is a life-threatening illness with high incidence of ocular involvement. 2. Conjunctivitis is the commonest acute ophthalmic manifestation. 3. Early interference and active treatment regimen can reduce the events and further extent of corneal involvement.
Authors and Affiliations
Rema Devi S, Ajith Chakravarthy
Keywords
Related Articles
- EP ID EP418286
- DOI 10.14260/jemds/2018/544
- Views 78
- Downloads 0
PREVALENCE OF BACTERIAL VAGINOSIS IN PREGNANCY AFTER 20 WEEKS OF GESTATION
BACKGROUND Bacterial vaginosis (BV) is an extremely prevalent vaginal condition and the number one cause of vaginitis among both pregnant and non-pregnant women. Aims and Objective- To study the prevalence of bacterial v...
IMAGING OF BREAST LESIONS USING CONVENTIONAL MAGNETIC RESONANCE IMAGING AND DIFFUSION WEIGHTED IMAGING
[b]CONTEXT:[/b] Breast cancer is the second most common cancer in the world, and the second most common in cancer in Indian women. [b]AIMS[/b]: The aims of this study were to differentiate between benign and...
ONLAY MESH REPAIR OF INCISIONAL HERNIA IS EFFECTIVE WITH LOW RECURRENCE AND COMPLICATIONS
BACKGROUND Incisional hernia after abdominal surgery is a well-known complication. Controversy still exists with respect to the choice of hernia repair technique. Aims and Objectives- To study the complications and recur...
MRI IN PAEDIATRIC INHERITED METABOLIC BRAIN DISORDERS
AIMS AND OBJECTIVES To emphasize the role of MRI in paediatric inherited metabolic brain disorders and to study the varied spectrum of imaging findings in these disease entities and to highlight the importance...
EVALUATION OF TRIPLE ASSESSMENT FOR DIAGNOSIS OF BREAST CANCER IN A TERTIARY CENTRE
BACKGROUND Breast is a specialised accessory (modified sweat gland) of skin capable of milk secretion. Breast diseases may present with lump, nipple discharge or retraction, mastalgia etc. Benign lesion of breast commonl...