A Clinicopathological Study of Paediatric Liver Tumours in a Tertiary Care Hospital
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 3
Abstract
Introduction: Paediatric primary liver tumours are the third largest group of solid abdominal neoplasms in children next to neuroblastoma and Wilms tumour, accounting for about 0.5% to 2% of all paediatric neoplasms, in which hepatoblastoma is the most common. Aim: The present study was done to estimate the incidence of paediatric liver tumours over a period of five years and also, to study the clinical behaviour, alpha-fetoprotein correlation and histopathological features of paediatric liver tumours. Materials and Methods: The details of patients treated for paediatric liver tumours for a period of five years were retrospectively retrieved from the tumour board and medical records. The gross features and all the slides were reviewed and the pathologic diagnosis was confirmed and clinicopathological correlation was then done. Results: A total of 39 paediatric liver tumours were detected during five years, of which 32 (82%) were malignant and seven (18%) were benign with a male to female ratio of 1:1.1. Hepatoblastoma was the most common liver tumour accounting for 28 cases (71.8%), of which 25 cases (89.4%) were of pure epithelial type. The second most common primary tumour was epithelioid haemangioendothelioma with six cases (15.4%) with female preponderance, followed by two cases each of hepatocellular carcinoma and undifferentiated embryonal sarcoma and one case of hepatocellular adenoma. Serum AFP level was increased in hepatoblastoma and in hepatocellular carcinoma, normal in hepatocellular adenoma and embryonal sarcoma. Serum AFP level was increased in few cases of epithelioid haemangioendothelioma. Conclusion: The spectrum of liver tumours in children is different from that in the adults. Hepatoblastoma is the most common paediatric liver tumour, followed by epithelioid haemangioendothelioma. Through better understanding of pathological diagnosis, refined surgical staging, newer and more effective radiological techniques and standardized multimodal therapies, a substantial number of children diagnosed with this highly malignant tumour can expect to survive the disease.
Authors and Affiliations
Esakki Muthuvel, Vimal Chander, Chitra Srinivasan
Keywords
Related Articles
- EP ID EP334173
- DOI 10.7860/JCDR/2017/24223.9592
- Views 106
- Downloads 0
Ultrasound-Guided Extraoral Removal of Extraparenchymal Sialoliths Caused by Acute Parotitis
ABSTRACT Migration of sialoliths is extremely rare and is presumed to be a consequence of abscess formation. We report a minimally invasive, ultrasound-guided, extraoral approach for the removal of extraparenchymal sialo...
Golden Hours in Severe Paraquat Poisoning-The Role of Early Haemoperfusion Therapy
Introduction: Paraquat is a commonly ingested poison especially in Southern India. There is no antidote for paraquat poison and consumption is often fatal. The usual cause of death is either acute lung injury or multi-or...
Effect of Spinal Manipulation on Pain Sensitivity, Postural Sway, and Health-related Quality of Life among Patients with Non-specific Chronic Low Back Pain: A Randomised Control Trial
ABSTRACT Introduction: Spinal manipulation is a technique of specific directed manual thrust which has been effective in aligning a spinal segment, maintaining normal range of motion and reducing pain. Recent studies hav...
Risk of GERD with Diabetes Mellitus, Hypertension and Bronchial Asthma – A Hospital based Retrospective Cohort Study
Introduction: The rise in Gastro-Esophageal Reflux Disease (GERD) prevalence appears to have coincided with a simultaneous increase in the prevalence of diabetes mellitus, hypertension and bronchial asthma amongst the In...
Cluster Headache in a Case of Ophthalmic Cysticercosis
ABSTRACT Cluster headache is considered to be a primary headache. A lot of literature has been published for apparent cluster headache like conditions arising out of organic pathologies like tumours, dissection and infec...