A Clinicopathological Study of Urothelial Carcinoma and Its Correlation with Her2/Neu Expression.
Journal Title: International Journal of Medical Science And Advanced Clinical Research (IJMACR) - Year 2019, Vol 2, Issue 3
Abstract
Introduction: Urothelial Carcinoma is one of the most prevalent cancers in men. Patients presented with varied symptoms like hematuria, dysuria, urgency, frequency. HER2/neu expressions have found to be related to many cancers like breast, prostate, stomach. Despite many reports in the literature the prognostic significance of its overexpression in urothelial carcinoma remains unclear. Aim: To study the relationship between tumour grade and Clinical Presentation and correlation of HER2/neu with tumour grade. Material and Methods: 117 cases of urothelial carcinoma were diagnosed in our department between January 2016 and July 2017. The tumour specimens obtained by transurethral resection and cystectomy were evaluated by immunohistochemistry using HER2/neu antibody. Result HER2/neu overexpression was present in 78/117 (66.66%) of cases with 60/75 (80%) in high grade tumours and 18/42 (42.85%) in low grade tumours. Conclusion: There was a significant correlation between HER2/neu expression and grade of the tumour. Thus this knowledge can be used for Targeted therapy in future, but no correlation was found between clinical features and Grade of the tumour.
Authors and Affiliations
Dr. Gyanendra
Keywords
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