A Clinicopathological Study of Urothelial Carcinoma and Its Correlation with Her2/Neu Expression.
Journal Title: International Journal of Medical Science And Advanced Clinical Research (IJMACR) - Year 2019, Vol 2, Issue 3
Abstract
Introduction: Urothelial Carcinoma is one of the most prevalent cancers in men. Patients presented with varied symptoms like hematuria, dysuria, urgency, frequency. HER2/neu expressions have found to be related to many cancers like breast, prostate, stomach. Despite many reports in the literature the prognostic significance of its overexpression in urothelial carcinoma remains unclear. Aim: To study the relationship between tumour grade and Clinical Presentation and correlation of HER2/neu with tumour grade. Material and Methods: 117 cases of urothelial carcinoma were diagnosed in our department between January 2016 and July 2017. The tumour specimens obtained by transurethral resection and cystectomy were evaluated by immunohistochemistry using HER2/neu antibody. Result HER2/neu overexpression was present in 78/117 (66.66%) of cases with 60/75 (80%) in high grade tumours and 18/42 (42.85%) in low grade tumours. Conclusion: There was a significant correlation between HER2/neu expression and grade of the tumour. Thus this knowledge can be used for Targeted therapy in future, but no correlation was found between clinical features and Grade of the tumour.
Authors and Affiliations
Dr. Gyanendra
Keywords
Related Articles
- EP ID EP589782
- DOI -
- Views 94
- Downloads 0
A Clinical Study of 10% Lignocaine Spray For Attenuation of Hemodynamic Response to Direct Laryngoscopy
Introduction: Hemodynamic response to Laryngoscopy is a well-known problem since long time and there are many studies conducted to attenuate this pressure response, the present study is undertaken to study the effect of...
A Cephalometric Study of Breathing Mode Influence on Dentofacial Morphology in Children of 6 To 12 Years
Background Mouth breathing is seen to cause facial and structural growth alterations, especially during childhood and has been discussed in medical and dental literature, since ages. The change in mode of respiration cau...
Red Blood Cell Indices Along With Hemoglobin and Serum Ferritin Estimation At Internal Correlation In Pregnant Females
Introduction: Anaemias occurring during pregnancy are known to increase maternal and perinatal morbidity and mortality, therefore it would be therapeutically important to be capable of selecting women who are in iron def...
A unusual three way complex rearrangement t(6;8,21)(p23;q22;q22) with RUNX1/RUNX1T1 fusion resulting in partial trisomy for region 8q22 to 8qter : a new variant of t(8;21) in acute myeloid leukemia(M2)
Background: Acute myeloid leukemia (AML) with t(8;21)(q22;q22) : RUNX1-RUNX1T1 fusion is a distinct type of acute myeloid leukemia (AML), especially in FAB M2. AML with t(8;21)(q22;q22) is associated with a favorable pro...
Fahr’s Disease with Secondary Hyperparathyroidism
Fahr’s syndrome refers to a rare syndrome which is characterized by symmetrical and bilateral intracranial calcification.1,2 Here we present a case of a 48 year old male patient , who presented to our...