A Comparasion of Perioperative Ramosetron and Ramosetron with Dexamethasone Prophylaxis for the Prevention of Postoperative Nausea and Vomiting Following Laparoscopic Cholecystectomy under General Anaesthesia
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Introduction: Post Operative Nausea and Vomiting (PONV) is a well known complication following laparoscopic cholecystectomy under general anaesthesia ranges from 53-72 %. A reduction in the incidence of PONV following laparoscopic cholecystectomy will be highly beneficial for the patients to avoid patient dissatisfaction and peri-operative morbidity. This study have been undertaken to find out the efficacy of combination therapy of ramosetron with dexamethasone for the prevention of PONV following laparoscopic cholecystectomy under general anaesthesia. Methods: 30 patients in each study group, age 18-65 years of either sex with ASA class I and II, scheduled for elective laparoscopic cholecystectomy under standardized general anaesthesia were enrolled in this randomized, double blind prospective study. Medication was given intravenously immediately before administration of induction agent. Enrolled patients were divided into two groups as RD group (ramosetron 0.3 mg with dexamethasone 6 mg and R group (ramosetron 0.3 mg). The incidence of nausea, and vomiting, severity of nausea and need of rescue antiemetic were studied for the first 24 hours postoperatively at 0-6 hours and 6-24 hours and 0-24 hours. Results: The incidence of nausea, PONV, rescue antiemetic were reduced in the RD group during 0-6 hours post operative periods while the incidence of vomiting was significantly reduced in RD group during 0-6 hours post operative (P = 0.003). The severity of nausea which measured by VRS was also significantly lesser in the RD group (P = 0.00). There were no clinically significant adverse effects during the study which required intervention. Following the study, patients were reported to have experienced satisfactory postoperative period. Conclusions: Perioperative prophylaxis of ramosetron with dexamethasone combination given before the induction of anaesthesia is more effective regimen than ramosetron alone in preventing the incidence of PONV after elective laparoscopic cholecystectomy under general anaesthesia.
Authors and Affiliations
Rakesh Nongthombam
Keywords
Related Articles
- EP ID EP284948
- DOI -
- Views 76
- Downloads 0
Prevalence of Gestational Diabetes Mellitus among Cohort of Pregnant Women Registered in Primary Health Center
Background: Gestational Diabetes Mellitus (GDM) is an important public health problem in India. The prevalence of GDM is constantly on the rise, globally. Women with GDM are at increased risk for adverse obstetric and pe...
Giant Serous Cyst adenoma of Ovary in an Adolescent Girl: Case Report
Ovarian neoplasia in pediatric population is rare. Serous cystadenoma is an uncommon ovarian tumor in the adolescent age group, arises from surface epithelium of ovary. We report a case of serous cystadenoma of ovary in...
Hematological Profile in Patients Suffering From Tuberculosis and Treatment Response
Background: Reversible peripheral blood abnormalities are commonly associated with pulmonary tuberculosis and these hematological changes act as marker for the diagnosis, prognosis and response to therapy. There is no co...
Clinical Study to Compare the Efficacy of Platelet Rich Plasma versus Conventional Dressing in Chronic Diabetic Non Healing Ulcers
Diabetic non healing ulcers are a frequent of amputation and represent substantial expenses to fitness care and decrease patient best of existence. The purpose of wound management is to attain wound closure as expeditiou...
Variations in the Blood Supply of Kidneys: Cadaveric and Autopsy Findings
Introduction: Renal arteries originates at right angle from the abdominal aorta just below the superior mesenteric artery at the level of intervertebral disc between L1 and L2 vertebra and take about 20% of the cardiac o...