A Comparasion of Perioperative Ramosetron and Ramosetron with Dexamethasone Prophylaxis for the Prevention of Postoperative Nausea and Vomiting Following Laparoscopic Cholecystectomy under General Anaesthesia
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Introduction: Post Operative Nausea and Vomiting (PONV) is a well known complication following laparoscopic cholecystectomy under general anaesthesia ranges from 53-72 %. A reduction in the incidence of PONV following laparoscopic cholecystectomy will be highly beneficial for the patients to avoid patient dissatisfaction and peri-operative morbidity. This study have been undertaken to find out the efficacy of combination therapy of ramosetron with dexamethasone for the prevention of PONV following laparoscopic cholecystectomy under general anaesthesia. Methods: 30 patients in each study group, age 18-65 years of either sex with ASA class I and II, scheduled for elective laparoscopic cholecystectomy under standardized general anaesthesia were enrolled in this randomized, double blind prospective study. Medication was given intravenously immediately before administration of induction agent. Enrolled patients were divided into two groups as RD group (ramosetron 0.3 mg with dexamethasone 6 mg and R group (ramosetron 0.3 mg). The incidence of nausea, and vomiting, severity of nausea and need of rescue antiemetic were studied for the first 24 hours postoperatively at 0-6 hours and 6-24 hours and 0-24 hours. Results: The incidence of nausea, PONV, rescue antiemetic were reduced in the RD group during 0-6 hours post operative periods while the incidence of vomiting was significantly reduced in RD group during 0-6 hours post operative (P = 0.003). The severity of nausea which measured by VRS was also significantly lesser in the RD group (P = 0.00). There were no clinically significant adverse effects during the study which required intervention. Following the study, patients were reported to have experienced satisfactory postoperative period. Conclusions: Perioperative prophylaxis of ramosetron with dexamethasone combination given before the induction of anaesthesia is more effective regimen than ramosetron alone in preventing the incidence of PONV after elective laparoscopic cholecystectomy under general anaesthesia.
Authors and Affiliations
Rakesh Nongthombam
Keywords
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