A Comparative analysis: In-vitro dissolution study of different commercially available brands of diclofenac sodium
Journal Title: Pakistan Journal of Pharmaceutical Research - Year 2018, Vol 4, Issue 2
Abstract
The study was aimed to compare in-vitro release behavior of four commercially available brands of diclofenac sodium sustained release tablets. Most commonly used brands of tablets were taken randomly that contained same quantity of active ingredients but differ in type or amount of excipients used. USP references standard Diclofenac Sodium was used to obtain standard curve. In-vitro dissolution was performed by USP Paddle apparatus employing two different dissolution medium one acidic (pH 1.2) and other buffer medium (pH 6.8). Weight variation of these formulations was found to be 1.4%, 2.1%, 2.6% and 0.9%. In-vitro dissolution rate of these commercially available brands of diclofenac sodium were 97.867%, 90.979%, 95.639% and 99.494% respectively. The result showed variability in release profile. Sustained quality control and constant market monitoring on these products and its formulation factors can lead to improvement in quality of medicine.
Authors and Affiliations
Huma butt
Keywords
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- EP ID EP630439
- DOI 10.22200/pjpr.2018121-25
- Views 128
- Downloads 0
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