A COMPARATIVE ANALYSIS OF ACUTE TOXICITIES IN HYPOFRACTIONATED RADIOTHERAPY VERSUS CONVENTIONAL RADIOTHERAPY IN EARLY-STAGE BREAST CANCER AFTER BREAST CONSERVATION SURGERY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 30
Abstract
BACKGROUND Adjuvant radiation to early breast cancer who underwent breast conservation can be delivered in two different fractionation schedules. Aim- Analysis of acute toxicities in hypofractionated radiotherapy versus conventional radiotherapy in early-stage breast cancer. MATERIALS AND METHODS This is a single institutional prospective non-randomised controlled trial done on patients with early breast cancer who underwent breast conservation surgery and required adjuvant radiation therapy in our hospital which is a tertiary care cancer hospital in South India. 40 patients with 20 in each arm, who were treated from June 2014 - January 2016 are included in the study. The reactions were graded according to the RTOG acute toxicity grading criteria. Pearson’s Chi-square test was used and a p-value of 0.05 was used for comparison of acute toxicity. Relation of breast volume to the grade of acute toxicity was analysed using ANOVA test. RESULTS This study with patient and tumour characteristics of both treatment groups were similar in age, tumour histology, tumour staging, nodal staging and hormone receptor status. In the conventional group, 15 patients (75%) had grade-2 reaction, 3 patients (15%) had grade-3 reactions, while in HF group most patients had grade-1 skin reactions (60%), 8 patients (40%) had grade-2 reactions and none of them showed grade-3 reactions. Analysis of acute toxicity showed statistical significance between both groups (p=0.002). In the CF group, 3 patients who had grade-3 skin reaction had a mean breast volume of 1484.67 cc (± 167 cc), 15 patients who had grade-2 skin reaction had a mean breast volume of 956 cc (± 219) and 2 patients who had grade-1 skin reaction had a mean breast volume of 622 cc (± 125 cc). In the HF group, the mean breast volume for 12 patients who had grade-1 skin toxicity is 763.83 cc (± 223) and for 8 patients who had grade-2 skin toxicity is 1197.50 cc (± 242.9). Higher the breast volume, higher is the grade of acute skin reaction in both the groups. CONCLUSION Hypofractionated radiotherapy can be recommended as a standard treatment after BCS with short duration of treatment and comparable skin toxicities with that of conventional radiotherapy.
Authors and Affiliations
Sukrutha Boggula, Ashwini Gopal, Suneetha Mulinti, Alluri Krishnam Raju
Keywords
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- EP ID EP538594
- DOI 10.14260/jemds/2018/755
- Views 73
- Downloads 0
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