A Comparative Analysis to Determine the Anti-Hypertensive Effect of Olmesartan Medoxomil and Enalapril
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 1
Abstract
Background: The industrial revolution, development and adoption of western life style have made hypertension a significant health problem in India and thus have adversely affected the cardiovascular haemodynamics. Olmesartan medoxomil, a prodrug, is hydrolyzed to olmesartan during absorption from the gastrointestinal tract. Olmesartan is a selective AT1 subtype angiotensin II receptor antagonist. The aim of the present study is to determine the antihypertensive effect of olmesartan medoxomil and enalapril. Materials and Methods: The present prospective study was conducted in the medicine department of Rajindra Hospital, Patiala. All the patients reporting to the OPD of the department whether new hypertensive or previously suffering from Stage I or Stage II hypertension were included in the study. 50 patients were put on Olmesartan and 50 on Enalapril for the treatment of hypertension. All the data obtained was arranged in a tabulated form and analysed using SPSS software. Student t test was used a test for significance and p value of less than 0.05 was considered significant. Results: In group A (Olmesartan), 8 patients were in the age group 20-39 years, 24 patients were in the age group 40-59, 15 patients were in the age group 60-79, 3 patients were in the age group ≥80. In group B (Enalapril), 7(14%) patients were in the range of 45-54 kg, 16(32%) kg were in the range of 55-64 kg There was observed marked fall in SBP (mm Hg) with drug therapy in both groups. In group A (Olmesartan), the mean SBP (mm Hg) at the beginning of trial, at 4 weeks and at 8weeks was 162 ± 6.37, 152.2 ± 4.63 and 149.16 ± 5.62 respectively and the fall in SBP (mm Hg) with the treatment was statistically significant (p <0.05). Conclusion: On long term basis both the drugs are equally effective but immediate effect is seen by olmesartan.
Authors and Affiliations
Parminderpal Singh, Dr. Kiranjit, Shabdeep Kaur, Husan Pal
Keywords
Related Articles
- EP ID EP531141
- DOI 10.21276/ijmrp.2018.4.1.120
- Views 60
- Downloads 0
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