A COMPARATIVE CLINICAL EVALUATION OF ORAL CLONIDINE VS. PREGABALIN PREMEDICATION FOR ATTENUATION OF HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND INTUBATION- A PROSPECTIVE RANDOMISED DOUBLE BLINDED PLACEBOCONTROLLED STUDY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 9
Abstract
BACKGROUND Endotracheal intubation is considered gold standard in patients undergoing general anaesthesia. Direct laryngoscopy and tracheal intubation result in an increase in blood pressure and heart rate, the so called ‘pressor response’. Various techniques and drugs have been used in the past to attenuate the pressor response, however none has been proved to be ideal. We conducted this study to compare any possible blunting of cardiovascular effects of laryngoscopy and tracheal intubation by the use of 150 mg pregabalin or 200mcg clonidine with the group that did not receive any of the two drugs. MATERIALS AND METHODS 90 ASA Grade 1 and 2 patients aged 18-60 years of both genders were recruited for the study with 30 patients in each group. Group A – Received oral pregabalin 150 mg with sip of water 120 min before the surgery. Group B – Received oral clonidine 200 mcg with sip of water 120 min prior to surgery. Group C – Oral placebo (multivitamin) with sip of water 120 min prior to surgery. On arrival in the operating room, HR, SBP, DBP, MAP were recorded at baseline, after induction, 1-, 3-, 5- and 10-mins after laryngoscopy and intubation. RESULTS In this study, there was a significant reduction in HR, SBP, DBP, MAP after laryngoscopy and intubation in pregabalin and clonidine group in comparison to control group. Oral premedication with pregabalin as well as clonidine attenuates the haemodynamic response to laryngoscopy and intubation with clonidine being superior to pregabalin.
Authors and Affiliations
Megha Soni, Niharika Grover, Suvidha Sood
Keywords
Related Articles
- EP ID EP611580
- DOI 10.18410/jebmh/2019/143
- Views 65
- Downloads 0
A COMPARATIVE STUDY OF FUNCTIONAL OUTCOMES OF FRACTURE SHAFT HUMERUS IN ADULTS TREATED WITH DYNAMIC COMPRESSION PLATING AND INTERLOCKING NAILING
INTRODUCTION: Optimal method of humeral shaft fracture fixation remains in debate till date. Two techniques under study include intramedullary nailing and dynamic compression plate fixation. Plating provides satisfactory...
EFFICACY OF FINE-NEEDLE ASPIRATION TECHNIQUE, ZIEHL-NEELSEN STAINS AND CULTURE (BACTEC) IN DIAGNOSIS OF TUBERCULOUS LYMPHADENITIS IN A TERTIARY CARE HOSPITAL, GAYA, INDIA
BACKGROUND Tuberculous lymphadenitis is the commonest form of extrapulmonary tuberculosis and tissue diagnosis is the mainstay in the diagnosis of extrapulmonary tuberculosis. This study was conducted to compare cytology...
A RARE PRESENTATION OF ISOLATED ABDUCENS NERVE PALSY- REVISITING DORELLOGRADENIGO'S DEBATE
PRESENTATION OF THE CASE A 25-year-old male presented with diplopia in our outpatient department. On examination left eye, had esodeviation of 45 prism diopter, limitation of abduction, (Figures 1, 2.) with face turn to...
A RARE CASE REPORT OF A LARGE PLACENTAL CHORIOANGIOMA
BACKGROUND Chorioangioma is a relatively common benign tumour of placenta arising from chorionic tissue. The incidence of it is very rare around 0.6%. These often remain unnoticed as they are rarely more than 5 cm. CASE...
FUNCTIONAL ANALYSIS OF PROXIMAL FEMORAL FRACTURES TREATED WITH PROXIMAL FEMORAL NAIL
BACKGROUND Intertrochanteric femoral fractures are of intense interest globally. They are the most frequently operated fractures and they have the highest postoperative fatality rate of surgically-treated fractures and h...