A COMPARATIVE CLINICAL EVALUATION OF ORAL CLONIDINE VS. PREGABALIN PREMEDICATION FOR ATTENUATION OF HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND INTUBATION- A PROSPECTIVE RANDOMISED DOUBLE BLINDED PLACEBOCONTROLLED STUDY

Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 9

Abstract

BACKGROUND Endotracheal intubation is considered gold standard in patients undergoing general anaesthesia. Direct laryngoscopy and tracheal intubation result in an increase in blood pressure and heart rate, the so called ‘pressor response’. Various techniques and drugs have been used in the past to attenuate the pressor response, however none has been proved to be ideal. We conducted this study to compare any possible blunting of cardiovascular effects of laryngoscopy and tracheal intubation by the use of 150 mg pregabalin or 200mcg clonidine with the group that did not receive any of the two drugs. MATERIALS AND METHODS 90 ASA Grade 1 and 2 patients aged 18-60 years of both genders were recruited for the study with 30 patients in each group. Group A – Received oral pregabalin 150 mg with sip of water 120 min before the surgery. Group B – Received oral clonidine 200 mcg with sip of water 120 min prior to surgery. Group C – Oral placebo (multivitamin) with sip of water 120 min prior to surgery. On arrival in the operating room, HR, SBP, DBP, MAP were recorded at baseline, after induction, 1-, 3-, 5- and 10-mins after laryngoscopy and intubation. RESULTS In this study, there was a significant reduction in HR, SBP, DBP, MAP after laryngoscopy and intubation in pregabalin and clonidine group in comparison to control group. Oral premedication with pregabalin as well as clonidine attenuates the haemodynamic response to laryngoscopy and intubation with clonidine being superior to pregabalin.

Authors and Affiliations

Megha Soni, Niharika Grover, Suvidha Sood

Keywords

Related Articles

ASSESSMENT OF FOETAL COMPROMISE BY DOPPLER ULTRASOUND INVESTIGATION OF THE FOETAL CIRCULATION

BACKGROUND The condition in which the foetus does not reach its growth potential is called Intrauterine Growth Restricted (IUGR). The mothers who are generally healthy and well nourished, the incidence of IUGR is 3-5%. T...

KNUCKLE HYPERPIGMENTATION IS A MARKER OF VITAMIN B12 DEFICIENCY IN VEGETARIAN POPULATION

BACKGROUND B12 deficiency is common in India as is Vitamin D, folic acid, or iron deficiency. Megaloblastic Anaemia due to vitamin B12 deficiency is extremely common in the predominantly vegetarian population. The sympto...

IMPACT OF CLINICAL PHARMACIST COUNSELLING ON HEALTH RELATED QUALITY OF LIFE IN PATIENTS WITH OBSTRUCTIVE PULMONARY DISEASES

BACKGROUND Obstructive pulmonary diseases include Chronic Obstructive Pulmonary Disease (COPD), Bronchial Asthma, Bronchiectasis, Small Airway Disease (Bronchiolitis). Among these, Bronchial Asthma and COPD are included...

PROSPECTIVE STUDY OF CYTO HISTOPATHOLOGICAL CORRELATION OF BREAST LESIONS

INTRODUCTION: Cancer of breast is the second most common cause of cancer in women. In the present era, late marriage, late child birth, shorter period of breast feeding and nulliparity or low parity have contributed to i...

A STUDY ON MACROSCOPIC ANATOMY OF HUMAN PLACENTA

It is only the eutherian mammals that have evolved a complex organ - “The Placenta” which not only protect but also gives nutrition to the embryo till its birth. We should see that the placenta is more than just some mes...

Download PDF file
  • EP ID EP611580
  • DOI 10.18410/jebmh/2019/143
  • Views 64
  • Downloads 0

How To Cite

Megha Soni, Niharika Grover, Suvidha Sood (2019). A COMPARATIVE CLINICAL EVALUATION OF ORAL CLONIDINE VS. PREGABALIN PREMEDICATION FOR ATTENUATION OF HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND INTUBATION- A PROSPECTIVE RANDOMISED DOUBLE BLINDED PLACEBOCONTROLLED STUDY. Journal of Evidence Based Medicine and Healthcare, 6(9), 684-690. https://europub.co.uk/articles/-A-611580