A COMPARATIVE CLINICAL OUTCOME STUDY OF DESCEMET MEMBRANE ENDOTHELIAL KERATOPLASTY (DMEK) AND TRADITIONAL DESCEMET STRIPPING ENDOTHELIAL KERATOPLASTY (DSEK) IN INTERVENTIONAL PROSPECTIVE OUTCOMES
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 49
Abstract
BACKGROUND Patients presenting to the eye clinics with endothelial decomposition who underwent endothelial keratoplasty were included in the study. Data including patient demographics, visual acuity, endothelial cell counts, and complications were recorded at baseline as well as 3 and 6 months and 1 year post-operatively. The primary outcome for this study was BCVA at 6 months and 1 year. Secondary outcomes included endothelial cell counts and complication rates. MATERIALS AND METHODS A total of 100 consecutive eye patients which met inclusion criteria underwent endothelial keratoplasty and were included in this study. RESULTS Of these 50 patients’ eyes had DSEK, while other 50 patients’ eyes had DMEK. After controlling for baseline visual acuity study, participants undergoing DMEK had better improvement in visual acuity compared with DSEK in early postoperative period, but not at 6 months (p= 0.310) and 1-year (p= 0.105) follow-up. DMEK patients experienced an average of 34.75% endothelial cell loss compared with 33.5% in DSEK at the end of 1-year. There were 2 primary graft failures after DMEK compared with 0 after DSEK, but this was not a statistically significant difference (p= 0.0475). CONCLUSION In early post-operative period, DMEK offers a visual improvement in the early post-operative period but had more endothelial cell loss. However, at the end of 1-year follow-up, difference between the two procedures gradually narrowed down in terms of BCVA and ECL (Endothelial Cell Loss).
Authors and Affiliations
Dharamveer Singh Choudhary, Anamika Chaudhary, Nikhil Aggarwal, Mahendra Kumar Jharwal, Bhavit Roat
Keywords
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- EP ID EP549016
- DOI 10.14260/jemds/2018/1159
- Views 61
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