A comparative evaluation of Losartan/Hydrochlorothiazide (fixed combination) versus Amlodipine monotherapy in patients with hypertension in Rohilkhand region
Journal Title: Internet Journal of Medical Update - Year 2014, Vol 9, Issue 2
Abstract
The aim of this prospective randomized study is to comparatively evaluate the antihypertensive efficacy of combination therapy (losartan/hydrochlorothiazide) with monotherapy (amlodipine). This prospective randomized clinical study was carried out for twelve months (July 2012 – June 2013) and enrolled 250 newly diagnosed stage-I hypertensive patients (as per JNC-7 criteria), who attended medicine outdoor department of Rohilkhand Medical College & Hospital, Bareilly. Hypertensive patients between 18 - 70 years of age were included in the study. The patients were randomly divided into two groups. The Losartan / Hydrochlorothiazide (LST/HCTZ) group included 128 patients and amlodipine group (AMLO) included 122 patients. A total of 40 patients, 14 patients of LST/HCTZ group and 26 patients of AMLO group dropped out during the study. M/F ratio was 0.92:1, and urban/rural ratio was 1.06:1. Majority of patients were in the 41-50 years age group. Mean systolic blood pressure (SBP) and mean diastolic blood pressure (DBP) were comparable between both groups, being 152.97 mm Hg and 95.05mm Hg for LST/HCTZ group and 153.27mm Hg and 95.27 mm Hg for AMLO group. Both mean SBP and mean DBP blood were statistically significantly reduced in each of the six follow ups in both the groups (p<0.001). The mean SBP was reduced from 152.97±0.45 to 121.65±0.81 and mean DBP was reduced from 95.05±0.17 to 76.28±0.51(in the sixth follow-up) in LST/HCTZ group. Similarly mean baseline SBP 153.270±64 was reduced to 120.65±0.93 and mean baseline DBP was reduced from 95.270±38 to 75.54±0.67 after six months of therapy in AMLO group. The comparative evaluation of the two regimens revealed no statistically significant difference (p>0.05) in both SBP and DBP reduction. Both LST/HCTZ and AMLO regimen were equally effective and well tolerated in lowering blood pressure.
Authors and Affiliations
Iram Shaifali, A Kapoor, R Patial
Keywords
Related Articles
- EP ID EP162864
- DOI -
- Views 85
- Downloads 0
Sister Mary Joseph’s Nodule: A short compilation
No
Peripheral gangrene in a child as a result of Primary Thrombocytosis
Essential Thrombocytosis (ET) is a clonal disorder of unknown etiology involving a multipotent hematopoietic progenitor cell and is manifested clinically by the overproduction of platelets without a definable cause. Clin...
Does the clinical profile of Gujarati patients with Takayasu’s aortoarteritis differ from other Indians?
Takayasu’s aortoarteritis is a well-known yet rare form of large vessel vasculitis. It is a chronic inflammatory diseas, which has remained an enigma since it was first described a century ago. The present study was done...
Management, treatment outcome and cost of epilepsy in a tertiary health care facility in northern Nigeria
This study aimed at reviewing the management and treatment outcome, and evaluating economic burden of antiepileptic drugs (AEDs) in Ahmadu Bello University Teaching Hospital, Kaduna (ABUTH). It was a retrospective study...
‘Radiopath’- an assimilation of radiology and pathology: a need of the day