A comparative study between clonidine and dexmedetomidine in attenuation of pressor response during endotracheal intubation
Journal Title: Indian Journal of Clinical Anaesthesia - Year 2018, Vol 5, Issue 2
Abstract
Aims 1To study and compare efficiency of clonidine and dexmedetomidine to reduce haemodynamic response ie attenuation of pressor response to laryngoscopy and tracheal intubation with single premedication dose2 To evaluate dose sparing effect of clonidine and dexmedetomidine on induction agentMaterials and Methods 60 patients physical status ASA grade I and II were randomized into two groups C and D n 30 in each group Group C received 1gkg of clonidine while group D received 1gkg of dexmedetomidine preoperatively over 10 minutes before induction through syringe infusion pump Each patient was induced with injection Thiopentone sodium until loss of eyelash reflex After check ventilation succinylcholine 2 mgkg was given followed by tracheal intubation Anaesthesia was maintained with O2 N2O5050 and Vecuronium supplemented with isoflurane Hemodynamic parameters were recordedResults We observed no statistical difference in heart rate blood pressure systolic diastolic and mean arterial pressure between the two groups from baseline up to induction between two groups Group C had higher readings of HR SBP DBP and MAP compared to group D after intubation upto 3 min which was statistically significant Induction dose of thiopentone was lower in dexmedetomidine group and was statistically significantConclusion Dexmedetomidine attenuated the hemodynamic pressor response and also reduces the dose requirement of thiopentone sodium and was superior to clonidineKeywords Clonidine Dexmedetomidine Premedication Pressor response
Authors and Affiliations
Ganesh Nikam, Madhukrishna N.
Keywords
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- EP ID EP476461
- DOI 10.18231/2394-4994.2018.0045
- Views 107
- Downloads 0
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