A Comparative Study between Conventional Dressing (With Betadine, Antibiotic Ointment, Eusol and Normal Saline) of Ulcer and Dressing with Triple Helical Collagen
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
BACKGROUND: Skin is the natural covering of the human body and is the largest organ by virtue of its extensive surface area. It serves a variety of functions ranging from protection of the underlying tissue to the maintenance of haemostasis. The skin is subjected to a variety of insults ranging from external trauma, infectious disease, noxious stimuli, and internal metabolic disorder. Ulcers are defined simply as a break in the continuity of the covering epithelium, mucous membrane or skin. In recent years several new treatment strategies emerge to stimulate wound healing. There are topical growth factors, extracellular matrix products, bioengineered skin and granulocytes macrophages colony stimulating factors. New advanced topical dressings are emerging that improve wound care. Such dressings are designed to modulate levels of biological molecules such as growth factors that may promote wound healing. Important examples of such dressing are collagen granules, hyaluronic acid cream, PDGF cream feracrrylum gel etc. PATIENTS AND METHOD: This is prospective study conducted on 100 cases of symptomatic ulcer cases admitted in Surgical Wards of J.L.N. Medical College, Ajmer. All patients will be divided in two groups of 50 patients each. First group will undergo dressing with lyphophillized triple helical bovine collagen; second group will undergo conventional dressing with betadine, antibiotic ointment, EUSOL and normal saline. Further the healing process and results were analyzed. RESULTS AND CONCLUSION: Most of the patients were males, with age group ranging from 41-60yrs; most common site was foot, with diabetes being the main culprit followed by the infective etiology. At the end of 1st week, 50% shows complete or near complete healing in collagen group as compared to 8% in control group, this further observed to be 74% & 24% after 2nd week, 82% & 44% after 4th week and 94% & 64% after 6th week. There was significant difference in the result of collagen granules and conventional dressing. Collagen granules had better healing response rate and occasionally dramatic response. We conclude that collagen granules are a useful topical agent to be applied locally to all types of ulcers except malignant ulcers. Collagen granules enhances the healing process, as evident by early appearance of red granulation tissue and epithelization, smaller lag period in healing and early completion of healing of ulcers.
Authors and Affiliations
Dr. Mukesh Bagari, Dr. Sami Anwar Khan, Dr. Shalu gupta, Dr. Brijesh Mathur, Dr. Ashok Meghwal
Keywords
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- EP ID EP554057
- DOI 10.9790/0853-1803026672.
- Views 91
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