A comparative Study between Cyproheptadine and Amitriptyline in the Treatment of Tension Type Headache

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A comparative Study between Cyproheptadine and Amitriptyline in the Treatment of Tension Type Headache

Journal Title: Nepal Journal of Neuroscience - Year 2008, Vol 5, Issue 1

Abstract

The objective of this prospective study of patients with Tension Type Headache in Neurology Clinic in a tertiary referral hospital in Nepal was to compare the efficacy of the drug Cyproheptadine with Amitriptyline in the treatment/prophylaxis of Tension Type Headache........................................ Of the total 66 cases selected for the study, 32 cases were randomly selected to be treated with the antihistamine Cyproheptadine, and 34 were randomly assigned to be treated with tricyclic antidepressant A m i t r i p t y l i n e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . In the Cyproheptadine group, a significant improvement of headache was seen in 25%, mild improvement in 38%, and no improvement in 38%. In the Tension Type Headache group treated with the Amitriptyline, a comparable result of significant improvement was seen in 24% ,mild improvement seen in 42% , and 35% showed no change. In the treatment of tension type headache, Cyproheptadine is comparable to Amitriptyline in terms of efficacy.

Authors and Affiliations

Rabindra Shrestha, MD

Keywords

Amitriptyline Cyproheptadine Tension Type Headache

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EP ID EP370711
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