A Comparative Study between Intramuscular and Oral Methylprednisolone Acetate in the Treatment of Asthma Exacerbation Following Discharge from the Hospital
Journal Title: Journal of Chalmeda AnandRao Institute of Medical Sciences - Year 2018, Vol 15, Issue 1
Abstract
ABSTRACT Aims and Objectives: To compare the efficacy of long acting Intamuscular methylprednisolone to tapering oral doses of methylprednisolone in reducing the relapse rates in adult asthmatic patients discharged from the hospital following an exacerbation. Materials and Methods: This comparative study was conducted in the Department of Pulmonology in Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar from November 2015 to June 2017. This comparative study was conducted on 100 known asthma patients having asthma exacerbations. Results: 10 day relapse rates are 14.58% (95% CI=4.6% to 24.56%) and 14.28% (95% CI=4.48% to 24.08%) with intramuscular and oral methylprednisolone preparations respectively. 21day relapse rates are 18.75% (95% CI = 7.71% to 29.79%) and 20.40% (95% CI=9.12% to 31.68%) with intramuscular and oral methylprednisolone respectively. Conclusion: Single-dose IM methylprednisolone administered to adult asthmatic patients at ED discharge appears to be a viable therapeutic alternative to a course of oral methylprednisolone.
Authors and Affiliations
Kishore Kumar K, Sai Samrat K, Sony Reddy S
Keywords
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